Difference between revisions of "YPL209C"
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| − | '''Description of {{PAGENAME}}:''' Aurora kinase involved in regulating kinetochore-microtubule attachments; helps maintain condensed chromosomes during anaphase and early telophase; associates with Sli15p, which promotes Ipl1p association with mitotic spindle<ref name='S000119930'>Vas AC, et al. ( | + | '''Description of {{PAGENAME}}:''' Aurora kinase involved in regulating kinetochore-microtubule attachments; helps maintain condensed chromosomes during anaphase and early telophase; associates with Sli15p, which promotes Ipl1p association with mitotic spindle<ref name='S000119930'>Vas AC, et al. (2007) In Vivo Analysis of Chromosome Condensation in Saccharomyces cerevisiae. Mol Biol Cell 18(2):557-68 {{SGDpaper|S000119930}} PMID 17151360</ref><ref name='S000071581'>Cheeseman IM, et al. (2002) Phospho-regulation of kinetochore-microtubule attachments by the Aurora kinase Ipl1p. Cell 111(2):163-72 {{SGDpaper|S000071581}} PMID 12408861</ref><ref name='S000066223'>Kang J, et al. (2001) Functional cooperation of Dam1, Ipl1, and the inner centromere protein (INCENP)-related protein Sli15 during chromosome segregation. J Cell Biol 155(5):763-74 |
{{SGDpaper|S000066223}} PMID 11724818</ref> | {{SGDpaper|S000066223}} PMID 11724818</ref> | ||
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| + | Specifically higher expression in carbon limited chemostat cultures versus carbon excess. | ||
| + | <ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. | ||
| + | J Biol Chem 278(5):3265-74</ref> | ||
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Revision as of 13:02, 21 February 2007
Share your knowledge...Edit this entry! <protect>
| Systematic name | YPL209C |
| Gene name | IPL1 |
| Aliases | PAC15 |
| Feature type | ORF, Verified |
| Coordinates | Chr XVI:157592..156489 |
Description of YPL209C: Aurora kinase involved in regulating kinetochore-microtubule attachments; helps maintain condensed chromosomes during anaphase and early telophase; associates with Sli15p, which promotes Ipl1p association with mitotic spindle[1][2][3]
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Contents
Community Commentary
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Alleles, Strains, and Phenotypes
Point Mutation
Allele: ipl1-321
Strain Background: W303
Phenotype(s): Temperature(Heat) Sensitive
Impairing Ipl1p function restores chromosome attachment in the mtw1-1 mutant , suggesting that Ipl1p promotes the turnover of improper kinetochore-microtubule interactions. [4] [5]
Protein Details
Protein Modification
Modification(s): Phosphorylation
Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [6] [7]
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References
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- ↑ Vas AC, et al. (2007) In Vivo Analysis of Chromosome Condensation in Saccharomyces cerevisiae. Mol Biol Cell 18(2):557-68 SGD PMID 17151360
- ↑ Cheeseman IM, et al. (2002) Phospho-regulation of kinetochore-microtubule attachments by the Aurora kinase Ipl1p. Cell 111(2):163-72 SGD PMID 12408861
- ↑ Kang J, et al. (2001) Functional cooperation of Dam1, Ipl1, and the inner centromere protein (INCENP)-related protein Sli15 during chromosome segregation. J Cell Biol 155(5):763-74 SGD PMID 11724818
- ↑ Pinsky BA, et al. (2003) An Mtw1 complex promotes kinetochore biorientation that is monitored by the Ipl1/Aurora protein kinase. Dev Cell 5(5):735-45 SGD PMID 14602074
- ↑ submitted by Benjamin Pinsky on 2004-03-04
- ↑ Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
- ↑ submitted by Jeff Ubersax on 2004-01-29
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