YPL209C

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Systematic name YPL209C
Gene name IPL1
Aliases PAC15
Feature type ORF, Verified
Coordinates Chr XVI:157593..156490
Primary SGDID S000006130


Description of YPL209C: Aurora kinase subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), involved in regulating kinetochore-microtubule attachments; helps maintain condensed chromosomes during anaphase and early telophase; required for SPB cohesion and prevention of multipolar spindle formation[1][2][3][4][5]




Contents

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Alleles, Strains, and Phenotypes

Point Mutation

Allele: ipl1-321

Strain Background: W303 (see detailed notes from Rodney Rothstein and Stephan Bartsch for the W303 strain used in the study)
Phenotype(s): Temperature(Heat) Sensitive

Impairing Ipl1p function restores chromosome attachment in the mtw1-1 mutant , suggesting that Ipl1p promotes the turnover of improper kinetochore-microtubule interactions. [6] [7]


Protein Details

Protein Modification

Modification(s): Phosphorylation

Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [8] [9]





References

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  1. Cheeseman IM, et al. (2002) Phospho-regulation of kinetochore-microtubule attachments by the Aurora kinase Ipl1p. Cell 111(2):163-72 SGD PMID 12408861
  2. Kang Js JS, et al. (2001) Functional cooperation of Dam1, Ipl1, and the inner centromere protein (INCENP)-related protein Sli15 during chromosome segregation. J Cell Biol 155(5):763-74 SGD PMID 11724818
  3. Nakajima Y, et al. (2009) Nbl1p: a Borealin/Dasra/CSC-1-like protein essential for Aurora/Ipl1 complex function and integrity in Saccharomyces cerevisiae. Mol Biol Cell 20(6):1772-84 SGD PMID 19158380
  4. Shirk K, et al. (2011) The Aurora kinase Ipl1 is necessary for spindle pole body cohesion during budding yeast meiosis. J Cell Sci 124(Pt 17):2891-6 SGD PMID 21878496
  5. Vas AC, et al. (2007) In vivo analysis of chromosome condensation in Saccharomyces cerevisiae. Mol Biol Cell 18(2):557-68 SGD PMID 17151360
  6. Pinsky BA, et al. (2003) An Mtw1 complex promotes kinetochore biorientation that is monitored by the Ipl1/Aurora protein kinase. Dev Cell 5(5):735-45 SGD PMID 14602074
  7. submitted by Benjamin Pinsky on 2004-03-04
  8. Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
  9. submitted by Jeff Ubersax on 2004-01-29

See Help:Categories on how to add the wiki page for this gene to a Category

References

See Help:References on how to add references

  1. Cheeseman IM, et al. (2002) Phospho-regulation of kinetochore-microtubule attachments by the Aurora kinase Ipl1p. Cell 111(2):163-72 SGD PMID 12408861
  2. Kang Js JS, et al. (2001) Functional cooperation of Dam1, Ipl1, and the inner centromere protein (INCENP)-related protein Sli15 during chromosome segregation. J Cell Biol 155(5):763-74 SGD PMID 11724818
  3. Nakajima Y, et al. (2009) Nbl1p: a Borealin/Dasra/CSC-1-like protein essential for Aurora/Ipl1 complex function and integrity in Saccharomyces cerevisiae. Mol Biol Cell 20(6):1772-84 SGD PMID 19158380
  4. Shirk K, et al. (2011) The Aurora kinase Ipl1 is necessary for spindle pole body cohesion during budding yeast meiosis. J Cell Sci 124(Pt 17):2891-6 SGD PMID 21878496
  5. Vas AC, et al. (2007) In vivo analysis of chromosome condensation in Saccharomyces cerevisiae. Mol Biol Cell 18(2):557-68 SGD PMID 17151360
  6. Pinsky BA, et al. (2003) An Mtw1 complex promotes kinetochore biorientation that is monitored by the Ipl1/Aurora protein kinase. Dev Cell 5(5):735-45 SGD PMID 14602074
  7. submitted by Benjamin Pinsky on 2004-03-04
  8. Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
  9. submitted by Jeff Ubersax on 2004-01-29

See Help:Categories on how to add the wiki page for this gene to a Category

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