Difference between revisions of "YML028W"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?locus=YML028W YML028W]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000004490 YML028W]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''TSA1 ''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''TSA1 ''
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|nowrap| Chr XIII:220138..220728
 
|nowrap| Chr XIII:220138..220728
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000004490
 
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'''Description of {{PAGENAME}}:''' Ubiquitous housekeeping thioredoxin peroxidase, reduces reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; mediates redox regulation of the nuclear localization of Yap1p; deletion results in mutator phenotype<ref name='S000080858'>Okazaki S, et al. (2005) Peroxiredoxin-mediated redox regulation of the nuclear localization of Yap1, a transcription factor in budding yeast. Antioxid Redox Signal 7(3-4):327-34 {{SGDpaper|S000080858}} PMID 15706081</ref><ref name='S000076723'>Wong CM, et al. (2004) Peroxiredoxin-null yeast cells are hypersensitive to oxidative stress and are genomically unstable. J Biol Chem 279(22):23207-13 {{SGDpaper|S000076723}} PMID 15051715</ref><ref name='S000074096'>Huang ME, et al. (2003) A genomewide screen in Saccharomyces cerevisiae for genes that suppress the accumulation of mutations. Proc Natl Acad Sci U S A 100(20):11529-34 {{SGDpaper|S000074096}} PMID 12972632</ref><ref name='S000069194'>Wong CM, et al. (2002) Cooperation of yeast peroxiredoxins Tsa1p and Tsa2p in the cellular defense against oxidative and nitrosative stress. J Biol Chem 277(7):5385-94 {{SGDpaper|S000069194}} PMID 11741925</ref><ref name='S000057702'>Chae HZ, et al. (1993) Cloning, sequencing, and mutation of thiol-specific antioxidant gene of Saccharomyces cerevisiae. J Biol Chem 268(22):16815-21 {{SGDpaper|S000057702}} PMID 8344960</ref><ref name='S000057553'>Chae HZ, et al. (1994) Thioredoxin-dependent peroxide reductase from yeast. J Biol Chem 269(44):27670-8
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'''Description of YML028W:''' Thioredoxin peroxidase, acts as both a ribosome-associated and free cytoplasmic antioxidant; self-associates to form a high-molecular weight chaperone complex under oxidative stress; deletion results in mutator phenotype<ref name='S000057702'>Chae HZ, et al. (1993) Cloning, sequencing, and mutation of thiol-specific antioxidant gene of Saccharomyces cerevisiae. J Biol Chem 268(22):16815-21 {{SGDpaper|S000057702}} PMID 8344960</ref><ref name='S000057553'>Chae HZ, et al. (1994) Thioredoxin-dependent peroxide reductase from yeast. J Biol Chem 269(44):27670-8 {{SGDpaper|S000057553}} PMID 7961686</ref><ref name='S000074096'>Huang ME, et al. (2003) A genomewide screen in Saccharomyces cerevisiae for genes that suppress the accumulation of mutations. Proc Natl Acad Sci U S A 100(20):11529-34 {{SGDpaper|S000074096}} PMID 12972632</ref><ref name='S000080858'>Okazaki S, et al. (2005) Peroxiredoxin-mediated redox regulation of the nuclear localization of Yap1, a transcription factor in budding yeast. Antioxid Redox Signal 7(3-4):327-34 {{SGDpaper|S000080858}} PMID 15706081</ref><ref name='S000125540'>Trotter EW, et al. (2008) The yeast Tsa1 peroxiredoxin is a ribosome-associated antioxidant. Biochem J 412(1):73-80 {{SGDpaper|S000125540}} PMID 18271751</ref><ref name='S000069194'>Wong CM, et al. (2002) Cooperation of yeast peroxiredoxins Tsa1p and Tsa2p in the cellular defense against oxidative and nitrosative stress. J Biol Chem 277(7):5385-94 {{SGDpaper|S000069194}} PMID 11741925</ref><ref name='S000076723'>Wong CM, et al. (2004) Peroxiredoxin-null yeast cells are hypersensitive to oxidative stress and are genomically unstable. J Biol Chem 279(22):23207-13
  {{SGDpaper|S000057553}} PMID 7961686</ref>
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  {{SGDpaper|S000076723}} PMID 15051715</ref>
 
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==Community Commentary==
 
==Community Commentary==
 
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Specifically higher expression in carbon limited chemostat cultures versus carbon excess.
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<ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur.
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J Biol Chem 278(5):3265-74</ref>
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==References==
 
==References==
 
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Latest revision as of 07:45, 23 January 2012

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Systematic name YML028W
Gene name TSA1
Aliases TPX1, ZRG14
Feature type ORF, Verified
Coordinates Chr XIII:220138..220728
Primary SGDID S000004490


Description of YML028W: Thioredoxin peroxidase, acts as both a ribosome-associated and free cytoplasmic antioxidant; self-associates to form a high-molecular weight chaperone complex under oxidative stress; deletion results in mutator phenotype[1][2][3][4][5][6][7]




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References

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  1. Chae HZ, et al. (1993) Cloning, sequencing, and mutation of thiol-specific antioxidant gene of Saccharomyces cerevisiae. J Biol Chem 268(22):16815-21 SGD PMID 8344960
  2. Chae HZ, et al. (1994) Thioredoxin-dependent peroxide reductase from yeast. J Biol Chem 269(44):27670-8 SGD PMID 7961686
  3. Huang ME, et al. (2003) A genomewide screen in Saccharomyces cerevisiae for genes that suppress the accumulation of mutations. Proc Natl Acad Sci U S A 100(20):11529-34 SGD PMID 12972632
  4. Okazaki S, et al. (2005) Peroxiredoxin-mediated redox regulation of the nuclear localization of Yap1, a transcription factor in budding yeast. Antioxid Redox Signal 7(3-4):327-34 SGD PMID 15706081
  5. Trotter EW, et al. (2008) The yeast Tsa1 peroxiredoxin is a ribosome-associated antioxidant. Biochem J 412(1):73-80 SGD PMID 18271751
  6. Wong CM, et al. (2002) Cooperation of yeast peroxiredoxins Tsa1p and Tsa2p in the cellular defense against oxidative and nitrosative stress. J Biol Chem 277(7):5385-94 SGD PMID 11741925
  7. Wong CM, et al. (2004) Peroxiredoxin-null yeast cells are hypersensitive to oxidative stress and are genomically unstable. J Biol Chem 279(22):23207-13 SGD PMID 15051715

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