YML028W
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| Systematic name | YML028W |
| Gene name | TSA1 |
| Aliases | TPX1, ZRG14 |
| Feature type | ORF, Verified |
| Coordinates | Chr XIII:220138..220728 |
| Primary SGDID | S000004490 |
Description of YML028W: Thioredoxin peroxidase, acts as both a ribosome-associated and free cytoplasmic antioxidant; self-associates to form a high-molecular weight chaperone complex under oxidative stress; deletion results in mutator phenotype[1][2][3][4][5][6][7]
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References
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- Jump up ↑ Chae HZ, et al. (1993) Cloning, sequencing, and mutation of thiol-specific antioxidant gene of Saccharomyces cerevisiae. J Biol Chem 268(22):16815-21 SGD PMID 8344960
- Jump up ↑ Chae HZ, et al. (1994) Thioredoxin-dependent peroxide reductase from yeast. J Biol Chem 269(44):27670-8 SGD PMID 7961686
- Jump up ↑ Huang ME, et al. (2003) A genomewide screen in Saccharomyces cerevisiae for genes that suppress the accumulation of mutations. Proc Natl Acad Sci U S A 100(20):11529-34 SGD PMID 12972632
- Jump up ↑ Okazaki S, et al. (2005) Peroxiredoxin-mediated redox regulation of the nuclear localization of Yap1, a transcription factor in budding yeast. Antioxid Redox Signal 7(3-4):327-34 SGD PMID 15706081
- Jump up ↑ Trotter EW, et al. (2008) The yeast Tsa1 peroxiredoxin is a ribosome-associated antioxidant. Biochem J 412(1):73-80 SGD PMID 18271751
- Jump up ↑ Wong CM, et al. (2002) Cooperation of yeast peroxiredoxins Tsa1p and Tsa2p in the cellular defense against oxidative and nitrosative stress. J Biol Chem 277(7):5385-94 SGD PMID 11741925
- Jump up ↑ Wong CM, et al. (2004) Peroxiredoxin-null yeast cells are hypersensitive to oxidative stress and are genomically unstable. J Biol Chem 279(22):23207-13 SGD PMID 15051715
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