Difference between revisions of "YML028W"

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==Community Commentary==
 
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==References==
 
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Revision as of 08:18, 30 January 2007

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Systematic name YML028W
Gene name TSA1
Aliases TPX1, ZRG14
Feature type ORF, Verified
Coordinates Chr XIII:220138..220728


Description of YML028W: Ubiquitous housekeeping thioredoxin peroxidase, reduces reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; mediates redox regulation of the nuclear localization of Yap1p; deletion results in mutator phenotype[1][2][3][4][5][6]




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Community Commentary

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References

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  1. Okazaki S, et al. (2005) Peroxiredoxin-mediated redox regulation of the nuclear localization of Yap1, a transcription factor in budding yeast. Antioxid Redox Signal 7(3-4):327-34 SGD PMID 15706081
  2. Wong CM, et al. (2004) Peroxiredoxin-null yeast cells are hypersensitive to oxidative stress and are genomically unstable. J Biol Chem 279(22):23207-13 SGD PMID 15051715
  3. Huang ME, et al. (2003) A genomewide screen in Saccharomyces cerevisiae for genes that suppress the accumulation of mutations. Proc Natl Acad Sci U S A 100(20):11529-34 SGD PMID 12972632
  4. Wong CM, et al. (2002) Cooperation of yeast peroxiredoxins Tsa1p and Tsa2p in the cellular defense against oxidative and nitrosative stress. J Biol Chem 277(7):5385-94 SGD PMID 11741925
  5. Chae HZ, et al. (1993) Cloning, sequencing, and mutation of thiol-specific antioxidant gene of Saccharomyces cerevisiae. J Biol Chem 268(22):16815-21 SGD PMID 8344960
  6. Chae HZ, et al. (1994) Thioredoxin-dependent peroxide reductase from yeast. J Biol Chem 269(44):27670-8 SGD PMID 7961686

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