Difference between revisions of "YML013W"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000004475 YML013W] |
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||'' | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''UBX2 '' |
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases''' ||'' | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases''' ||''SEL1'' |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type''' || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]] | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type''' || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]] | ||
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|nowrap| Chr XIII:244149..245903 | |nowrap| Chr XIII:244149..245903 | ||
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| − | | | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000004475 |
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| − | '''Description of | + | '''Description of YML013W:''' Bridging factor involved in ER-associated protein degradation (ERAD); bridges the cytosolic Cdc48p-Npl1p-Ufd1p ATPase complex and the membrane associated Ssm4p and Hrd1p ubiquitin ligase complexes; contains a UBX (ubiquitin regulatory X) domain and a ubiquitin-associated (UBA) domain; redistributes from the ER to lipid droplets during the diauxic shift and stationary phase; required for the maintenance of lipid homeostasis<ref name='S000072522'>Bartkeviciute D and Sasnauskas K (2003) Studies of yeast Kluyveromyces lactis mutations conferring super-secretion of recombinant proteins. Yeast 20(1):1-11 {{SGDpaper|S000072522}} PMID 12489121</ref><ref name='S000137819'>Neuber O, et al. (2005) Ubx2 links the Cdc48 complex to ER-associated protein degradation. Nat Cell Biol 7(10):993-8 {{SGDpaper|S000137819}} PMID 16179953</ref><ref name='S000086792'>Schuberth C and Buchberger A (2005) Membrane-bound Ubx2 recruits Cdc48 to ubiquitin ligases and their substrates to ensure efficient ER-associated protein degradation. Nat Cell Biol 7(10):999-1006 {{SGDpaper|S000086792}} PMID 16179952</ref><ref name='S000076733'>Schuberth C, et al. (2004) Shp1 and Ubx2 are adaptors of Cdc48 involved in ubiquitin-dependent protein degradation. EMBO Rep 5(8):818-24 {{SGDpaper|S000076733}} PMID 15258615</ref><ref name='S000148892'>Wang CW and Lee SC (2012) The ubiquitin-like (UBX)-domain-containing protein Ubx2/ Ubxd8 regulates lipid droplet homeostasis. J Cell Sci () |
| − | {{SGDpaper| | + | {{SGDpaper|S000148892}} PMID 22454508</ref> |
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==Community Commentary== | ==Community Commentary== | ||
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| + | <!-- PLEASE ADD Community Commentary ABOVE THIS MESSAGE. See below for an example of community annotation --> | ||
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| + | Specifically higher expression in carbon limited chemostat cultures versus carbon excess. | ||
| + | <ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. | ||
| + | J Biol Chem 278(5):3265-74</ref> | ||
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==References== | ==References== | ||
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Latest revision as of 14:05, 12 April 2012
Share your knowledge...Edit this entry! <protect>
| Systematic name | YML013W |
| Gene name | UBX2 |
| Aliases | SEL1 |
| Feature type | ORF, Verified |
| Coordinates | Chr XIII:244149..245903 |
| Primary SGDID | S000004475 |
Description of YML013W: Bridging factor involved in ER-associated protein degradation (ERAD); bridges the cytosolic Cdc48p-Npl1p-Ufd1p ATPase complex and the membrane associated Ssm4p and Hrd1p ubiquitin ligase complexes; contains a UBX (ubiquitin regulatory X) domain and a ubiquitin-associated (UBA) domain; redistributes from the ER to lipid droplets during the diauxic shift and stationary phase; required for the maintenance of lipid homeostasis[1][2][3][4][5]
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Contents
Community Commentary
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References
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- ↑ Bartkeviciute D and Sasnauskas K (2003) Studies of yeast Kluyveromyces lactis mutations conferring super-secretion of recombinant proteins. Yeast 20(1):1-11 SGD PMID 12489121
- ↑ Neuber O, et al. (2005) Ubx2 links the Cdc48 complex to ER-associated protein degradation. Nat Cell Biol 7(10):993-8 SGD PMID 16179953
- ↑ Schuberth C and Buchberger A (2005) Membrane-bound Ubx2 recruits Cdc48 to ubiquitin ligases and their substrates to ensure efficient ER-associated protein degradation. Nat Cell Biol 7(10):999-1006 SGD PMID 16179952
- ↑ Schuberth C, et al. (2004) Shp1 and Ubx2 are adaptors of Cdc48 involved in ubiquitin-dependent protein degradation. EMBO Rep 5(8):818-24 SGD PMID 15258615
- ↑ Wang CW and Lee SC (2012) The ubiquitin-like (UBX)-domain-containing protein Ubx2/ Ubxd8 regulates lipid droplet homeostasis. J Cell Sci () SGD PMID 22454508
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