YML013W

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Systematic name YML013W
Gene name UBX2
Aliases SEL1
Feature type ORF, Verified
Coordinates Chr XIII:244149..245903
Primary SGDID S000004475


Description of YML013W: Bridging factor involved in ER-associated protein degradation (ERAD); bridges the cytosolic Cdc48p-Npl1p-Ufd1p ATPase complex and the membrane associated Ssm4p and Hrd1p ubiquitin ligase complexes; contains a UBX (ubiquitin regulatory X) domain and a ubiquitin-associated (UBA) domain; redistributes from the ER to lipid droplets during the diauxic shift and stationary phase; required for the maintenance of lipid homeostasis[1][2][3][4][5]




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References

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  1. Bartkeviciute D and Sasnauskas K (2003) Studies of yeast Kluyveromyces lactis mutations conferring super-secretion of recombinant proteins. Yeast 20(1):1-11 SGD PMID 12489121
  2. Neuber O, et al. (2005) Ubx2 links the Cdc48 complex to ER-associated protein degradation. Nat Cell Biol 7(10):993-8 SGD PMID 16179953
  3. Schuberth C and Buchberger A (2005) Membrane-bound Ubx2 recruits Cdc48 to ubiquitin ligases and their substrates to ensure efficient ER-associated protein degradation. Nat Cell Biol 7(10):999-1006 SGD PMID 16179952
  4. Schuberth C, et al. (2004) Shp1 and Ubx2 are adaptors of Cdc48 involved in ubiquitin-dependent protein degradation. EMBO Rep 5(8):818-24 SGD PMID 15258615
  5. Wang CW and Lee SC (2012) The ubiquitin-like (UBX)-domain-containing protein Ubx2/ Ubxd8 regulates lipid droplet homeostasis. J Cell Sci () SGD PMID 22454508

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