Difference between revisions of "YLR133W"

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Specifically higher expression in carbon limited chemostat cultures versus carbon excess.
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<ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur.
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J Biol Chem 278(5):3265-74</ref>
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Revision as of 13:02, 21 February 2007

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Systematic name YLR133W
Gene name CKI1
Aliases
Feature type ORF, Verified
Coordinates Chr XII:408446..410194


Description of YLR133W: Choline kinase, catalyzes the first step in the CDP-choline pathway phosphatidylcholine synthesis (Kennedy pathway); mRNA expression is regulated by inositol and choline, enzyme activity is stimulated by phosphorylation by protein kinase[1][2][3][4]




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References

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  1. Kim KH, et al. (1998) Expression, purification, and characterization of choline kinase, product of the CKI gene from Saccharomyces cerevisiae. J Biol Chem 273(12):6844-52 SGD PMID 9506987
  2. Dowd SR, et al. (2001) Turnover of phosphatidylcholine in Saccharomyces cerevisiae. The role of the CDP-choline pathway. J Biol Chem 276(6):3756-63 SGD PMID 11078727
  3. Hosaka K, et al. (1989) Cloning and characterization of the yeast CKI gene encoding choline kinase and its expression in Escherichia coli. J Biol Chem 264(4):2053-9 SGD PMID 2536698
  4. Hosaka K, et al. (1990) Repression of choline kinase by inositol and choline in Saccharomyces cerevisiae. J Bacteriol 172(4):2005-12 SGD PMID 2156807

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