YLR133W

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Systematic name YLR133W
Gene name CKI1
Aliases
Feature type ORF, Verified
Coordinates Chr XII:408445..410193
Primary SGDID S000004123


Description of YLR133W: Choline kinase, catalyzing the first step in phosphatidylcholine synthesis via the CDP-choline (Kennedy pathway); exhibits some ethanolamine kinase activity contributing to phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway[1][2][3][4]




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References

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  1. Dowd SR, et al. (2001) Turnover of phosphatidylcholine in Saccharomyces cerevisiae. The role of the CDP-choline pathway. J Biol Chem 276(6):3756-63 SGD PMID 11078727
  2. Hosaka K, et al. (1989) Cloning and characterization of the yeast CKI gene encoding choline kinase and its expression in Escherichia coli. J Biol Chem 264(4):2053-9 SGD PMID 2536698
  3. Kim K, et al. (1999) Isolation and characterization of the Saccharomyces cerevisiae EKI1 gene encoding ethanolamine kinase. J Biol Chem 274(21):14857-66 SGD PMID 10329685
  4. Kim KH, et al. (1998) Expression, purification, and characterization of choline kinase, product of the CKI gene from Saccharomyces cerevisiae. J Biol Chem 273(12):6844-52 SGD PMID 9506987

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