Difference between revisions of "YLL027W"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000003950 YLL027W] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''ISA1 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''ISA1 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr XII: | + | |nowrap| Chr XII:87403..88155 |
|- | |- | ||
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000003950 | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000003950 | ||
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| − | '''Description of YLL027W:''' | + | '''Description of YLL027W:''' Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa2p and possibly Iba57p; isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency; depletion reduces growth on nonfermentable carbon sources; functional ortholog of bacterial A-type ISC proteins<ref name='S000043306'>Jensen LT and Culotta VC (2000) Role of Saccharomyces cerevisiae ISA1 and ISA2 in iron homeostasis. Mol Cell Biol 20(11):3918-27 {{SGDpaper|S000043306}} PMID 10805735</ref><ref name='S000070337'>Muhlenhoff U, et al. (2002) Characterization of iron-sulfur protein assembly in isolated mitochondria. A requirement for ATP, NADH, and reduced iron. J Biol Chem 277(33):29810-6 {{SGDpaper|S000070337}} PMID 12065597</ref><ref name='S000147072'>Muhlenhoff U, et al. (2011) SPECIALIZED FUNCTION OF YEAST ISA1 AND ISA2 IN THE MATURATION OF MITOCHONDRIAL [4FE-4S] PROTEINS. J Biol Chem () |
| − | {{SGDpaper| | + | {{SGDpaper|S000147072}} PMID 21987576</ref> |
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Latest revision as of 07:45, 23 January 2012
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| Systematic name | YLL027W |
| Gene name | ISA1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XII:87403..88155 |
| Primary SGDID | S000003950 |
Description of YLL027W: Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa2p and possibly Iba57p; isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency; depletion reduces growth on nonfermentable carbon sources; functional ortholog of bacterial A-type ISC proteins[1][2][3]
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References
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- ↑ Jensen LT and Culotta VC (2000) Role of Saccharomyces cerevisiae ISA1 and ISA2 in iron homeostasis. Mol Cell Biol 20(11):3918-27 SGD PMID 10805735
- ↑ Muhlenhoff U, et al. (2002) Characterization of iron-sulfur protein assembly in isolated mitochondria. A requirement for ATP, NADH, and reduced iron. J Biol Chem 277(33):29810-6 SGD PMID 12065597
- ↑ Muhlenhoff U, et al. (2011) SPECIALIZED FUNCTION OF YEAST ISA1 AND ISA2 IN THE MATURATION OF MITOCHONDRIAL [4FE-4S] PROTEINS. J Biol Chem () SGD PMID 21987576
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