YLL027W
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| Systematic name | YLL027W |
| Gene name | ISA1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XII:87403..88155 |
| Primary SGDID | S000003950 |
Description of YLL027W: Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa2p and possibly Iba57p; isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency; depletion reduces growth on nonfermentable carbon sources; functional ortholog of bacterial A-type ISC proteins[1][2][3]
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References
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- ↑ Jensen LT and Culotta VC (2000) Role of Saccharomyces cerevisiae ISA1 and ISA2 in iron homeostasis. Mol Cell Biol 20(11):3918-27 SGD PMID 10805735
- ↑ Muhlenhoff U, et al. (2002) Characterization of iron-sulfur protein assembly in isolated mitochondria. A requirement for ATP, NADH, and reduced iron. J Biol Chem 277(33):29810-6 SGD PMID 12065597
- ↑ Muhlenhoff U, et al. (2011) SPECIALIZED FUNCTION OF YEAST ISA1 AND ISA2 IN THE MATURATION OF MITOCHONDRIAL [4FE-4S] PROTEINS. J Biol Chem () SGD PMID 21987576
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