Difference between revisions of "YHR099W"
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| − | '''Description of YHR099W:''' Subunit of SAGA and NuA4 histone acetyltransferase complexes; interacts with acidic activators (e.g., Gal4p) which leads to transcription activation; similar to human TRRAP, which is a cofactor for c-Myc mediated oncogenic transformation<ref name=' | + | '''Description of YHR099W:''' Subunit of SAGA and NuA4 histone acetyltransferase complexes; interacts with acidic activators (e.g., Gal4p) which leads to transcription activation; similar to human TRRAP, which is a cofactor for c-Myc mediated oncogenic transformation<ref name='S000075628'>Bhaumik SR, et al. (2004) In vivo target of a transcriptional activator revealed by fluorescence resonance energy transfer. Genes Dev 18(3):333-43 {{SGDpaper|S000075628}} PMID 14871930</ref><ref name='S000074790'>Brown CE, et al. (2001) Recruitment of HAT complexes by direct activator interactions with the ATM-related Tra1 subunit. Science 292(5525):2333-7 {{SGDpaper|S000074790}} PMID 11423663</ref><ref name='S000047630'>Grant PA, et al. (1998) The ATM-related cofactor Tra1 is a component of the purified SAGA complex. Mol Cell 2(6):863-7 {{SGDpaper|S000047630}} PMID 9885573</ref><ref name='S000053036'>Saleh A, et al. (1998) Tra1p is a component of the yeast Ada.Spt transcriptional regulatory complexes. J Biol Chem 273(41):26559-65 |
| − | {{SGDpaper| | + | {{SGDpaper|S000053036}} PMID 9756893</ref> |
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Revision as of 14:05, 25 February 2010
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| Systematic name | YHR099W |
| Gene name | TRA1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr VIII:302764..313998 |
| Primary SGDID | S000001141 |
Description of YHR099W: Subunit of SAGA and NuA4 histone acetyltransferase complexes; interacts with acidic activators (e.g., Gal4p) which leads to transcription activation; similar to human TRRAP, which is a cofactor for c-Myc mediated oncogenic transformation[1][2][3][4]
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References
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- ↑ Bhaumik SR, et al. (2004) In vivo target of a transcriptional activator revealed by fluorescence resonance energy transfer. Genes Dev 18(3):333-43 SGD PMID 14871930
- ↑ Brown CE, et al. (2001) Recruitment of HAT complexes by direct activator interactions with the ATM-related Tra1 subunit. Science 292(5525):2333-7 SGD PMID 11423663
- ↑ Grant PA, et al. (1998) The ATM-related cofactor Tra1 is a component of the purified SAGA complex. Mol Cell 2(6):863-7 SGD PMID 9885573
- ↑ Saleh A, et al. (1998) Tra1p is a component of the yeast Ada.Spt transcriptional regulatory complexes. J Biol Chem 273(41):26559-65 SGD PMID 9756893
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