YHR099W

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Systematic name YHR099W
Gene name TRA1
Aliases
Feature type ORF, Verified
Coordinates Chr VIII:302761..313995
Primary SGDID S000001141


Description of YHR099W: Subunit of SAGA and NuA4 histone acetyltransferase complexes; interacts with acidic activators (e.g., Gal4p) which leads to transcription activation; similar to human TRRAP, which is a cofactor for c-Myc mediated oncogenic transformation[1][2][3][4]




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References

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  1. Bhaumik SR, et al. (2004) In vivo target of a transcriptional activator revealed by fluorescence resonance energy transfer. Genes Dev 18(3):333-43 SGD PMID 14871930
  2. Brown CE, et al. (2001) Recruitment of HAT complexes by direct activator interactions with the ATM-related Tra1 subunit. Science 292(5525):2333-7 SGD PMID 11423663
  3. Grant PA, et al. (1998) The ATM-related cofactor Tra1 is a component of the purified SAGA complex. Mol Cell 2(6):863-7 SGD PMID 9885573
  4. Saleh A, et al. (1998) Tra1p is a component of the yeast Ada.Spt transcriptional regulatory complexes. J Biol Chem 273(41):26559-65 SGD PMID 9756893

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