YGR188C
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| Systematic name | YGR188C | |
| Gene name | BUB1 | |
| Aliases | ||
| Feature type | ORF, Verified | |
| Coordinates | Chr VII:875114..872049 | |
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Description of YGR188C: Protein kinase that forms a complex with Mad1p and Bub3p that is crucial in the checkpoint mechanism required to prevent cell cycle progression into anaphase in the presence of spindle damage, associates with centromere DNA via Skp1p[1][2][3][4]
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References
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- ↑ Kitagawa K, et al. (2003) Requirement of Skp1-Bub1 interaction for kinetochore-mediated activation of the spindle checkpoint. Mol Cell 11(5):1201-13 SGD PMID 12769845
- ↑ Brady DM and Hardwick KG (2000) Complex formation between Mad1p, Bub1p and Bub3p is crucial for spindle checkpoint function. Curr Biol 10(11):675-8 SGD PMID 10837255
- ↑ Roberts BT, et al. (1994) The Saccharomyces cerevisiae checkpoint gene BUB1 encodes a novel protein kinase. Mol Cell Biol 14(12):8282-91 SGD PMID 7969164
- ↑ Farr KA and Hoyt MA (1998) Bub1p kinase activates the Saccharomyces cerevisiae spindle assembly checkpoint. Mol Cell Biol 18(5):2738-47 SGD PMID 9566893
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