YGR188C
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| Systematic name | YGR188C |
| Gene name | BUB1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr VII:875109..872044 |
| Primary SGDID | S000003420 |
Description of YGR188C: Protein kinase involved in the cell cycle checkpoint into anaphase; forms complex with Mad1p and Bub3p crucial to preventing cell cycle progression into anaphase in the presence of spindle damage; CDC28-mediated phosphorylation at Bub1p-T566 is important for its degradation in anaphase and adaptation of the checkpoint to prolonged mitotic arrest, but not to its kinase activity or chromosome segregation function; associates with centromere DNA via Skp1p[1][2][3][4][5]
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References
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- ↑ Brady DM and Hardwick KG (2000) Complex formation between Mad1p, Bub1p and Bub3p is crucial for spindle checkpoint function. Curr Biol 10(11):675-8 SGD PMID 10837255
- ↑ Farr KA and Hoyt MA (1998) Bub1p kinase activates the Saccharomyces cerevisiae spindle assembly checkpoint. Mol Cell Biol 18(5):2738-47 SGD PMID 9566893
- ↑ Goto GH, et al. (2011) Bub1-mediated adaptation of the spindle checkpoint. PLoS Genet 7(1):e1001282 SGD PMID 21298086
- ↑ Kitagawa K, et al. (2003) Requirement of Skp1-Bub1 interaction for kinetochore-mediated activation of the spindle checkpoint. Mol Cell 11(5):1201-13 SGD PMID 12769845
- ↑ Roberts BT, et al. (1994) The Saccharomyces cerevisiae checkpoint gene BUB1 encodes a novel protein kinase. Mol Cell Biol 14(12):8282-91 SGD PMID 7969164
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