Difference between revisions of "YGR188C"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000003420 YGR188C] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''BUB1 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''BUB1 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr VII: | + | |nowrap| Chr VII:875109..872044 |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000003420 | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000003420 | ||
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| − | '''Description of YGR188C:''' Protein kinase | + | '''Description of YGR188C:''' Protein kinase involved in the cell cycle checkpoint into anaphase; forms complex with Mad1p and Bub3p crucial to preventing cell cycle progression into anaphase in the presence of spindle damage; CDC28-mediated phosphorylation at Bub1p-T566 is important for its degradation in anaphase and adaptation of the checkpoint to prolonged mitotic arrest, but not to its kinase activity or chromosome segregation function; associates with centromere DNA via Skp1p<ref name='S000053845'>Brady DM and Hardwick KG (2000) Complex formation between Mad1p, Bub1p and Bub3p is crucial for spindle checkpoint function. Curr Biol 10(11):675-8 {{SGDpaper|S000053845}} PMID 10837255</ref><ref name='S000045152'>Farr KA and Hoyt MA (1998) Bub1p kinase activates the Saccharomyces cerevisiae spindle assembly checkpoint. Mol Cell Biol 18(5):2738-47 {{SGDpaper|S000045152}} PMID 9566893</ref><ref name='S000145307'>Goto GH, et al. (2011) Bub1-mediated adaptation of the spindle checkpoint. PLoS Genet 7(1):e1001282 {{SGDpaper|S000145307}} PMID 21298086</ref><ref name='S000073469'>Kitagawa K, et al. (2003) Requirement of Skp1-Bub1 interaction for kinetochore-mediated activation of the spindle checkpoint. Mol Cell 11(5):1201-13 {{SGDpaper|S000073469}} PMID 12769845</ref><ref name='S000051781'>Roberts BT, et al. (1994) The Saccharomyces cerevisiae checkpoint gene BUB1 encodes a novel protein kinase. Mol Cell Biol 14(12):8282-91 |
| − | {{SGDpaper| | + | {{SGDpaper|S000051781}} PMID 7969164</ref> |
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Latest revision as of 07:45, 23 January 2012
Share your knowledge...Edit this entry! <protect>
| Systematic name | YGR188C |
| Gene name | BUB1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr VII:875109..872044 |
| Primary SGDID | S000003420 |
Description of YGR188C: Protein kinase involved in the cell cycle checkpoint into anaphase; forms complex with Mad1p and Bub3p crucial to preventing cell cycle progression into anaphase in the presence of spindle damage; CDC28-mediated phosphorylation at Bub1p-T566 is important for its degradation in anaphase and adaptation of the checkpoint to prolonged mitotic arrest, but not to its kinase activity or chromosome segregation function; associates with centromere DNA via Skp1p[1][2][3][4][5]
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References
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- ↑ Brady DM and Hardwick KG (2000) Complex formation between Mad1p, Bub1p and Bub3p is crucial for spindle checkpoint function. Curr Biol 10(11):675-8 SGD PMID 10837255
- ↑ Farr KA and Hoyt MA (1998) Bub1p kinase activates the Saccharomyces cerevisiae spindle assembly checkpoint. Mol Cell Biol 18(5):2738-47 SGD PMID 9566893
- ↑ Goto GH, et al. (2011) Bub1-mediated adaptation of the spindle checkpoint. PLoS Genet 7(1):e1001282 SGD PMID 21298086
- ↑ Kitagawa K, et al. (2003) Requirement of Skp1-Bub1 interaction for kinetochore-mediated activation of the spindle checkpoint. Mol Cell 11(5):1201-13 SGD PMID 12769845
- ↑ Roberts BT, et al. (1994) The Saccharomyces cerevisiae checkpoint gene BUB1 encodes a novel protein kinase. Mol Cell Biol 14(12):8282-91 SGD PMID 7969164
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