YER042W

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Systematic name YER042W
Gene name MXR1
Aliases MSRA
Feature type ORF, Verified
Coordinates Chr V:234936..235490
Primary SGDID S000000844


Description of YER042W: Peptide methionine sulfoxide reductase, reverses the oxidation of methionine residues; involved in oxidative damage repair, providing resistance to oxidative stress and regulation of lifespan[1][2][3][4]




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References

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  1. Le DT, et al. (2009) Functional Analysis of Free Methionine-R-sulfoxide Reductase from Saccharomyces cerevisiae. J Biol Chem 284(7):4354-64 SGD PMID 19049972
  2. Hanbauer I, et al. (2003) A homologue of elongation factor 1 gamma regulates methionine sulfoxide reductase A gene expression in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 100(14):8199-204 SGD PMID 12824466
  3. Moskovitz J, et al. (1998) Overexpression of peptide-methionine sulfoxide reductase in Saccharomyces cerevisiae and human T cells provides them with high resistance to oxidative stress. Proc Natl Acad Sci U S A 95(24):14071-5 SGD PMID 9826655
  4. Moskovitz J, et al. (1997) The yeast peptide-methionine sulfoxide reductase functions as an antioxidant in vivo. Proc Natl Acad Sci U S A 94(18):9585-9 SGD PMID 9275166

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