Difference between revisions of "YDR440W"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl? | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000002848 YDR440W] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''DOT1 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''DOT1 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
|nowrap| Chr IV:1342485..1344233 | |nowrap| Chr IV:1342485..1344233 | ||
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| + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000002848 | ||
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<br> | <br> | ||
| − | '''Description of | + | '''Description of YDR440W:''' Nucleosomal histone H3-Lys79 methylase, associates with transcriptionally active genes, functions in gene silencing at telomeres, most likely by directly modulating chromatin structure and Sir protein localization<ref name='S000074129'>Ng HH, et al. (2003) The Rtf1 component of the Paf1 transcriptional elongation complex is required for ubiquitination of histone H2B. J Biol Chem 278(36):33625-8 {{SGDpaper|S000074129}} PMID 12876293</ref><ref name='S000071371'>Lacoste N, et al. (2002) Disruptor of telomeric silencing-1 is a chromatin-specific histone H3 methyltransferase. J Biol Chem 277(34):30421-4 {{SGDpaper|S000071371}} PMID 12097318</ref><ref name='S000070056'>Ng HH, et al. (2002) Lysine methylation within the globular domain of histone H3 by Dot1 is important for telomeric silencing and Sir protein association. Genes Dev 16(12):1518-27 |
{{SGDpaper|S000070056}} PMID 12080090</ref> | {{SGDpaper|S000070056}} PMID 12080090</ref> | ||
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J Biol Chem 278(5):3265-74</ref> | J Biol Chem 278(5):3265-74</ref> | ||
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Revision as of 08:46, 27 February 2007
Share your knowledge...Edit this entry! <protect>
| Systematic name | YDR440W |
| Gene name | DOT1 |
| Aliases | PCH1 |
| Feature type | ORF, Verified |
| Coordinates | Chr IV:1342485..1344233 |
| Primary SGDID | S000002848 |
Description of YDR440W: Nucleosomal histone H3-Lys79 methylase, associates with transcriptionally active genes, functions in gene silencing at telomeres, most likely by directly modulating chromatin structure and Sir protein localization[1][2][3]
</protect>
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References
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- ↑ Ng HH, et al. (2003) The Rtf1 component of the Paf1 transcriptional elongation complex is required for ubiquitination of histone H2B. J Biol Chem 278(36):33625-8 SGD PMID 12876293
- ↑ Lacoste N, et al. (2002) Disruptor of telomeric silencing-1 is a chromatin-specific histone H3 methyltransferase. J Biol Chem 277(34):30421-4 SGD PMID 12097318
- ↑ Ng HH, et al. (2002) Lysine methylation within the globular domain of histone H3 by Dot1 is important for telomeric silencing and Sir protein association. Genes Dev 16(12):1518-27 SGD PMID 12080090
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