YDR440W
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| Systematic name | YDR440W |
| Gene name | DOT1 |
| Aliases | PCH1 |
| Feature type | ORF, Verified |
| Coordinates | Chr IV:1342493..1344241 |
| Primary SGDID | S000002848 |
Description of YDR440W: Nucleosomal histone H3-Lys79 methylase; methylation is required for telomeric silencing, meiotic checkpoint control, and DNA damage response[1][2][3][4]
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References
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- ↑ Game JC, et al. (2005) X-ray survival characteristics and genetic analysis for nine Saccharomyces deletion mutants that show altered radiation sensitivity. Genetics 169(1):51-63 SGD PMID 15371366
- ↑ San-Segundo PA and Roeder GS (2000) Role for the silencing protein Dot1 in meiotic checkpoint control. Mol Biol Cell 11(10):3601-15 SGD PMID 11029058
- ↑ Wysocki R, et al. (2005) Role of Dot1-dependent histone H3 methylation in G1 and S phase DNA damage checkpoint functions of Rad9. Mol Cell Biol 25(19):8430-43 SGD PMID 16166626
- ↑ van Leeuwen F, et al. (2002) Dot1p modulates silencing in yeast by methylation of the nucleosome core. Cell 109(6):745-56 SGD PMID 12086673
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