Difference between revisions of "YDR440W"

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{|{{Prettytable}} align = 'right' width = '200px'
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?locus=YDR440W YDR440W]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000002848 YDR440W]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''DOT1 ''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''DOT1 ''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
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|nowrap| Chr IV:1342485..1344233
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|nowrap| Chr IV:1342493..1344241
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000002848
 
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'''Description of {{PAGENAME}}:''' Nucleosomal histone H3-Lys79 methylase, associates with transcriptionally active genes, functions in gene silencing at telomeres, most likely by directly modulating chromatin structure and Sir protein localization<ref name='S000074129'>Ng HH, et al. (2003) The Rtf1 component of the Paf1 transcriptional elongation complex is required for ubiquitination of histone H2B. J Biol Chem 278(36):33625-8 {{SGDpaper|S000074129}} PMID 12876293</ref><ref name='S000071371'>Lacoste N, et al. (2002) Disruptor of telomeric silencing-1 is a chromatin-specific histone H3 methyltransferase. J Biol Chem 277(34):30421-4 {{SGDpaper|S000071371}} PMID 12097318</ref><ref name='S000070056'>Ng HH, et al. (2002) Lysine methylation within the globular domain of histone H3 by Dot1 is important for telomeric silencing and Sir protein association. Genes Dev 16(12):1518-27
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'''Description of YDR440W:''' Nucleosomal histone H3-Lys79 methylase; methylation is required for telomeric silencing, meiotic checkpoint control, and DNA damage response<ref name='S000082068'>Game JC, et al. (2005) X-ray survival characteristics and genetic analysis for nine Saccharomyces deletion mutants that show altered radiation sensitivity. Genetics 169(1):51-63 {{SGDpaper|S000082068}} PMID 15371366</ref><ref name='S000059155'>San-Segundo PA and Roeder GS (2000) Role for the silencing protein Dot1 in meiotic checkpoint control. Mol Biol Cell 11(10):3601-15 {{SGDpaper|S000059155}} PMID 11029058</ref><ref name='S000086737'>Wysocki R, et al. (2005) Role of Dot1-dependent histone H3 methylation in G1 and S phase DNA damage checkpoint functions of Rad9. Mol Cell Biol 25(19):8430-43 {{SGDpaper|S000086737}} PMID 16166626</ref><ref name='S000071381'>van Leeuwen F, et al. (2002) Dot1p modulates silencing in yeast by methylation of the nucleosome core. Cell 109(6):745-56
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  {{SGDpaper|S000070056}} PMID 12080090</ref>
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  {{SGDpaper|S000071381}} PMID 12086673</ref>
 
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==Community Commentary==
 
==Community Commentary==
 
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<!-- PLEASE ADD Community Commentary ABOVE THIS MESSAGE. See below for an example of community annotation -->
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Specifically higher expression in carbon limited chemostat cultures versus carbon excess.
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<ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur.
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J Biol Chem 278(5):3265-74</ref>
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Latest revision as of 07:45, 23 January 2012

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Systematic name YDR440W
Gene name DOT1
Aliases PCH1
Feature type ORF, Verified
Coordinates Chr IV:1342493..1344241
Primary SGDID S000002848


Description of YDR440W: Nucleosomal histone H3-Lys79 methylase; methylation is required for telomeric silencing, meiotic checkpoint control, and DNA damage response[1][2][3][4]




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References

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  1. ↑ Game JC, et al. (2005) X-ray survival characteristics and genetic analysis for nine Saccharomyces deletion mutants that show altered radiation sensitivity. Genetics 169(1):51-63 SGD PMID 15371366
  2. ↑ San-Segundo PA and Roeder GS (2000) Role for the silencing protein Dot1 in meiotic checkpoint control. Mol Biol Cell 11(10):3601-15 SGD PMID 11029058
  3. ↑ Wysocki R, et al. (2005) Role of Dot1-dependent histone H3 methylation in G1 and S phase DNA damage checkpoint functions of Rad9. Mol Cell Biol 25(19):8430-43 SGD PMID 16166626
  4. ↑ van Leeuwen F, et al. (2002) Dot1p modulates silencing in yeast by methylation of the nucleosome core. Cell 109(6):745-56 SGD PMID 12086673

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