Difference between revisions of "YDR135C"

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'''Description of YDR135C:''' Vacuolar glutathione S-conjugate transporter of the ATP-binding cassette family, has a role in detoxifying metals such as cadmium, mercury, and arsenite; also transports unconjugated bilirubin; similar to human cystic fibrosis protein CFTR<ref name='S000073594'>Gueldry O, et al. (2003) Ycf1p-dependent Hg(II) detoxification in Saccharomyces cerevisiae. Eur J Biochem 270(11):2486-96 {{SGDpaper|S000073594}} PMID 12755704</ref><ref name='S000044201'>Li ZS, et al. (1996) The yeast cadmium factor protein (YCF1) is a vacuolar glutathione S-conjugate pump. J Biol Chem 271(11):6509-17 {{SGDpaper|S000044201}} PMID 8626454</ref><ref name='S000054860'>Li ZS, et al. (1997) A new pathway for vacuolar cadmium sequestration in Saccharomyces cerevisiae: YCF1-catalyzed transport of bis(glutathionato)cadmium. Proc Natl Acad Sci U S A 94(1):42-7 {{SGDpaper|S000054860}} PMID 8990158</ref><ref name='S000041475'>Petrovic S, et al. (2000) The products of YCF1 and YLL015w (BPT1) cooperate for the ATP-dependent vacuolar transport of unconjugated bilirubin in Saccharomyces cerevisiae. Yeast 16(6):561-71 {{SGDpaper|S000041475}} PMID 10790694</ref><ref name='S000056085'>Szczypka MS, et al. (1994) A yeast metal resistance protein similar to human cystic fibrosis transmembrane conductance regulator (CFTR) and multidrug resistance-associated protein. J Biol Chem 269(36):22853-7
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'''Description of YDR135C:''' Vacuolar glutathione S-conjugate transporter; member of the ATP-binding cassette family; has a role in detoxifying metals such as cadmium, mercury, and arsenite; also transports unconjugated bilirubin, selenodigluthatione, and oxidized glutathione; similar to human cystic fibrosis protein CFTR<ref name='S000073594'>Gueldry O, et al. (2003) Ycf1p-dependent Hg(II) detoxification in Saccharomyces cerevisiae. Eur J Biochem 270(11):2486-96 {{SGDpaper|S000073594}} PMID 12755704</ref><ref name='S000146592'>Lazard M, et al. (2011) Selenodiglutathione uptake by the Saccharomyces cerevisiae vacuolar ABC-transporter Ycf1p.LID - 10.1111/j.1742-4658.2011.08318.x [doi] FEBS J () {{SGDpaper|S000146592}} PMID 21880115</ref><ref name='S000044201'>Li ZS, et al. (1996) The yeast cadmium factor protein (YCF1) is a vacuolar glutathione S-conjugate pump. J Biol Chem 271(11):6509-17 {{SGDpaper|S000044201}} PMID 8626454</ref><ref name='S000054860'>Li ZS, et al. (1997) A new pathway for vacuolar cadmium sequestration in Saccharomyces cerevisiae: YCF1-catalyzed transport of bis(glutathionato)cadmium. Proc Natl Acad Sci U S A 94(1):42-7 {{SGDpaper|S000054860}} PMID 8990158</ref><ref name='S000041475'>Petrovic S, et al. (2000) The products of YCF1 and YLL015w (BPT1) cooperate for the ATP-dependent vacuolar transport of unconjugated bilirubin in Saccharomyces cerevisiae. Yeast 16(6):561-71 {{SGDpaper|S000041475}} PMID 10790694</ref><ref name='S000056085'>Szczypka MS, et al. (1994) A yeast metal resistance protein similar to human cystic fibrosis transmembrane conductance regulator (CFTR) and multidrug resistance-associated protein. J Biol Chem 269(36):22853-7
 
  {{SGDpaper|S000056085}} PMID 7521334</ref>
 
  {{SGDpaper|S000056085}} PMID 7521334</ref>
 
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Revision as of 14:05, 21 September 2011

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Systematic name YDR135C
Gene name YCF1
Aliases
Feature type ORF, Verified
Coordinates Chr IV:727551..723004
Primary SGDID S000002542


Description of YDR135C: Vacuolar glutathione S-conjugate transporter; member of the ATP-binding cassette family; has a role in detoxifying metals such as cadmium, mercury, and arsenite; also transports unconjugated bilirubin, selenodigluthatione, and oxidized glutathione; similar to human cystic fibrosis protein CFTR[1][2][3][4][5][6]




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Protein Details

Protein Function/Process

Ycf1p was demonstrated to catalyze ATP-coupled transport of 73As(GS)3 into the vacuole. [7] [8]




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References

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  1. ↑ Gueldry O, et al. (2003) Ycf1p-dependent Hg(II) detoxification in Saccharomyces cerevisiae. Eur J Biochem 270(11):2486-96 SGD PMID 12755704
  2. ↑ Lazard M, et al. (2011) Selenodiglutathione uptake by the Saccharomyces cerevisiae vacuolar ABC-transporter Ycf1p.LID - 10.1111/j.1742-4658.2011.08318.x [doi] FEBS J () SGD PMID 21880115
  3. ↑ Li ZS, et al. (1996) The yeast cadmium factor protein (YCF1) is a vacuolar glutathione S-conjugate pump. J Biol Chem 271(11):6509-17 SGD PMID 8626454
  4. ↑ Li ZS, et al. (1997) A new pathway for vacuolar cadmium sequestration in Saccharomyces cerevisiae: YCF1-catalyzed transport of bis(glutathionato)cadmium. Proc Natl Acad Sci U S A 94(1):42-7 SGD PMID 8990158
  5. ↑ Petrovic S, et al. (2000) The products of YCF1 and YLL015w (BPT1) cooperate for the ATP-dependent vacuolar transport of unconjugated bilirubin in Saccharomyces cerevisiae. Yeast 16(6):561-71 SGD PMID 10790694
  6. ↑ Szczypka MS, et al. (1994) A yeast metal resistance protein similar to human cystic fibrosis transmembrane conductance regulator (CFTR) and multidrug resistance-associated protein. J Biol Chem 269(36):22853-7 SGD PMID 7521334
  7. ↑ Ghosh M, et al. (1999) Pathways of As(III) detoxification in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 96(9):5001-6 SGD PMID 10220408
  8. ↑ submitted by Barry Rosen on 2003-07-31

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