YDR135C
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| Systematic name | YDR135C |
| Gene name | YCF1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr IV:727551..723004 |
| Primary SGDID | S000002542 |
Description of YDR135C: Vacuolar glutathione S-conjugate transporter; member of the ATP-binding cassette family; has a role in detoxifying metals such as cadmium, mercury, and arsenite; also transports unconjugated bilirubin, selenodigluthatione, and oxidized glutathione; similar to human cystic fibrosis protein CFTR[1][2][3][4][5][6]
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Protein Details
Protein Function/Process
Ycf1p was demonstrated to catalyze ATP-coupled transport of 73As(GS)3 into the vacuole. [7] [8]
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References
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- ↑ Gueldry O, et al. (2003) Ycf1p-dependent Hg(II) detoxification in Saccharomyces cerevisiae. Eur J Biochem 270(11):2486-96 SGD PMID 12755704
- ↑ Lazard M, et al. (2011) Selenodiglutathione uptake by the Saccharomyces cerevisiae vacuolar ABC-transporter Ycf1p.LID - 10.1111/j.1742-4658.2011.08318.x [doi] FEBS J () SGD PMID 21880115
- ↑ Li ZS, et al. (1996) The yeast cadmium factor protein (YCF1) is a vacuolar glutathione S-conjugate pump. J Biol Chem 271(11):6509-17 SGD PMID 8626454
- ↑ Li ZS, et al. (1997) A new pathway for vacuolar cadmium sequestration in Saccharomyces cerevisiae: YCF1-catalyzed transport of bis(glutathionato)cadmium. Proc Natl Acad Sci U S A 94(1):42-7 SGD PMID 8990158
- ↑ Petrovic S, et al. (2000) The products of YCF1 and YLL015w (BPT1) cooperate for the ATP-dependent vacuolar transport of unconjugated bilirubin in Saccharomyces cerevisiae. Yeast 16(6):561-71 SGD PMID 10790694
- ↑ Szczypka MS, et al. (1994) A yeast metal resistance protein similar to human cystic fibrosis transmembrane conductance regulator (CFTR) and multidrug resistance-associated protein. J Biol Chem 269(36):22853-7 SGD PMID 7521334
- ↑ Ghosh M, et al. (1999) Pathways of As(III) detoxification in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 96(9):5001-6 SGD PMID 10220408
- ↑ submitted by Barry Rosen on 2003-07-31
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