Difference between revisions of "YDL003W"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000002161 YDL003W] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''MCD1 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''MCD1 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr IV: | + | |nowrap| Chr IV:444683..446383 |
| + | |- | ||
| + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000002161 | ||
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<br> | <br> | ||
| − | '''Description of | + | '''Description of YDL003W:''' Essential subunit of the cohesin complex required for sister chromatid cohesion in mitosis and meiosis; apoptosis induces cleavage and translocation of a C-terminal fragment to mitochondria; expression peaks in S phase<ref name='S000054347'>Guacci V, et al. (1997) A direct link between sister chromatid cohesion and chromosome condensation revealed through the analysis of MCD1 in S. cerevisiae. Cell 91(1):47-57 {{SGDpaper|S000054347}} PMID 9335334</ref><ref name='S000125750'>Yang H, et al. (2008) Cleavage of Mcd1 by Caspase-like Protease Esp1 Promotes Apoptosis in Budding Yeast. Mol Biol Cell 19(5):2127-34 |
| − | {{SGDpaper| | + | {{SGDpaper|S000125750}} PMID 18321989</ref> |
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{{CommentaryHelp}} | {{CommentaryHelp}} | ||
| + | Mcd1 also involves in hydrogen peroxide-induced apoptosis. Upon induction of cell death, Mcd1 is cleaved and the C-terminal fragment is translocated from nucleus into mitochondria, causing the decrease of mitochondrial membrane potential and the amplification of cell death in a cytochrome c-dependent manner. | ||
| + | MBC 19(5):2127-34,2008 | ||
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| + | <!-- PLEASE ADD Community Commentary ABOVE THIS MESSAGE. See below for an example of community annotation --> | ||
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| + | Specifically higher expression in carbon limited chemostat cultures versus carbon excess. | ||
| + | <ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. | ||
| + | J Biol Chem 278(5):3265-74</ref> | ||
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| + | <protect> | ||
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| + | ==References== | ||
| + | <!-- REFERENCES ARE AUTOMATICALLY GENERATED. PLEASE DON'T EDIT THIS SECTION--> | ||
| + | {{RefHelp}} | ||
| + | </protect> | ||
<protect> | <protect> | ||
==References== | ==References== | ||
Latest revision as of 07:45, 23 January 2012
Share your knowledge...Edit this entry! <protect>
| Systematic name | YDL003W |
| Gene name | MCD1 |
| Aliases | PDS3, RHC21, SCC1 |
| Feature type | ORF, Verified |
| Coordinates | Chr IV:444683..446383 |
| Primary SGDID | S000002161 |
Description of YDL003W: Essential subunit of the cohesin complex required for sister chromatid cohesion in mitosis and meiosis; apoptosis induces cleavage and translocation of a C-terminal fragment to mitochondria; expression peaks in S phase[1][2]
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Community Commentary
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Mcd1 also involves in hydrogen peroxide-induced apoptosis. Upon induction of cell death, Mcd1 is cleaved and the C-terminal fragment is translocated from nucleus into mitochondria, causing the decrease of mitochondrial membrane potential and the amplification of cell death in a cytochrome c-dependent manner. MBC 19(5):2127-34,2008
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References
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- ↑ Guacci V, et al. (1997) A direct link between sister chromatid cohesion and chromosome condensation revealed through the analysis of MCD1 in S. cerevisiae. Cell 91(1):47-57 SGD PMID 9335334
- ↑ Yang H, et al. (2008) Cleavage of Mcd1 by Caspase-like Protease Esp1 Promotes Apoptosis in Budding Yeast. Mol Biol Cell 19(5):2127-34 SGD PMID 18321989
See Help:Categories on how to add the wiki page for this gene to a Category </protect> <protect>
References
See Help:References on how to add references
See Help:Categories on how to add the wiki page for this gene to a Category </protect>
