YDL003W

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Systematic name YDL003W
Gene name MCD1
Aliases PDS3, RHC21, SCC1
Feature type ORF, Verified
Coordinates Chr IV:444683..446383
Primary SGDID S000002161


Description of YDL003W: Essential subunit of the cohesin complex required for sister chromatid cohesion in mitosis and meiosis; apoptosis induces cleavage and translocation of a C-terminal fragment to mitochondria; expression peaks in S phase[1][2]




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Community Commentary

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Mcd1 also involves in hydrogen peroxide-induced apoptosis. Upon induction of cell death, Mcd1 is cleaved and the C-terminal fragment is translocated from nucleus into mitochondria, causing the decrease of mitochondrial membrane potential and the amplification of cell death in a cytochrome c-dependent manner. MBC 19(5):2127-34,2008




References

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  1. Guacci V, et al. (1997) A direct link between sister chromatid cohesion and chromosome condensation revealed through the analysis of MCD1 in S. cerevisiae. Cell 91(1):47-57 SGD PMID 9335334
  2. Yang H, et al. (2008) Cleavage of Mcd1 by Caspase-like Protease Esp1 Promotes Apoptosis in Budding Yeast. Mol Biol Cell 19(5):2127-34 SGD PMID 18321989

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References

See Help:References on how to add references

  1. Guacci V, et al. (1997) A direct link between sister chromatid cohesion and chromosome condensation revealed through the analysis of MCD1 in S. cerevisiae. Cell 91(1):47-57 SGD PMID 9335334
  2. Yang H, et al. (2008) Cleavage of Mcd1 by Caspase-like Protease Esp1 Promotes Apoptosis in Budding Yeast. Mol Biol Cell 19(5):2127-34 SGD PMID 18321989

See Help:Categories on how to add the wiki page for this gene to a Category

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