Difference between revisions of "YBR274W"
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| − | '''Description of YBR274W:''' Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase<ref name='S000086075'>Chen Y and Sanchez Y (2004) Chk1 in the DNA damage response: conserved roles from yeasts to mammals. DNA Repair (Amst) 3(8-9):1025-32 {{SGDpaper|S000086075}} PMID 15279789</ref><ref name='S000075286'>Agarwal R, et al. (2003) Two distinct pathways for inhibiting pds1 ubiquitination in response to DNA damage. J Biol Chem 278(45):45027-33 {{SGDpaper|S000075286}} PMID 12947083</ref><ref name='S000075033'>Rouse J and Jackson SP (2002) Interfaces between the detection, signaling, and repair of DNA damage. Science 297(5581):547-51 {{SGDpaper|S000075033}} PMID 12142523 | + | '''Description of YBR274W:''' Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase<ref name='S000039903'>Liu Y, et al. (2000) Characterization of a Saccharomyces cerevisiae homologue of Schizosaccharomyces pombe Chk1 involved in DNA-damage-induced M-phase arrest. Mol Gen Genet 262(6):1132-46 {{SGDpaper|S000039903}} PMID 10660074</ref><ref name='S000060449'>Wang H, et al. (2001) Pds1 phosphorylation in response to DNA damage is essential for its DNA damage checkpoint function. Genes Dev 15(11):1361-72 {{SGDpaper|S000060449}} PMID 11390356</ref><ref name='S000086075'>Chen Y and Sanchez Y (2004) Chk1 in the DNA damage response: conserved roles from yeasts to mammals. DNA Repair (Amst) 3(8-9):1025-32 {{SGDpaper|S000086075}} PMID 15279789</ref><ref name='S000075286'>Agarwal R, et al. (2003) Two distinct pathways for inhibiting pds1 ubiquitination in response to DNA damage. J Biol Chem 278(45):45027-33 {{SGDpaper|S000075286}} PMID 12947083</ref><ref name='S000075033'>Rouse J and Jackson SP (2002) Interfaces between the detection, signaling, and repair of DNA damage. Science 297(5581):547-51 |
| − | + | {{SGDpaper|S000075033}} PMID 12142523</ref> | |
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Revision as of 14:05, 31 March 2009
Share your knowledge...Edit this entry! <protect>
| Systematic name | YBR274W |
| Gene name | CHK1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr II:749589..751172 |
| Primary SGDID | S000000478 |
Description of YBR274W: Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase[1][2][3][4][5]
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References
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- ↑ Liu Y, et al. (2000) Characterization of a Saccharomyces cerevisiae homologue of Schizosaccharomyces pombe Chk1 involved in DNA-damage-induced M-phase arrest. Mol Gen Genet 262(6):1132-46 SGD PMID 10660074
- ↑ Wang H, et al. (2001) Pds1 phosphorylation in response to DNA damage is essential for its DNA damage checkpoint function. Genes Dev 15(11):1361-72 SGD PMID 11390356
- ↑ Chen Y and Sanchez Y (2004) Chk1 in the DNA damage response: conserved roles from yeasts to mammals. DNA Repair (Amst) 3(8-9):1025-32 SGD PMID 15279789
- ↑ Agarwal R, et al. (2003) Two distinct pathways for inhibiting pds1 ubiquitination in response to DNA damage. J Biol Chem 278(45):45027-33 SGD PMID 12947083
- ↑ Rouse J and Jackson SP (2002) Interfaces between the detection, signaling, and repair of DNA damage. Science 297(5581):547-51 SGD PMID 12142523
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