YBR274W
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| Systematic name | YBR274W |
| Gene name | CHK1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr II:749594..751177 |
| Primary SGDID | S000000478 |
Description of YBR274W: Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase[1][2][3][4][5]
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References
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- ↑ Agarwal R, et al. (2003) Two distinct pathways for inhibiting pds1 ubiquitination in response to DNA damage. J Biol Chem 278(45):45027-33 SGD PMID 12947083
- ↑ Chen Y and Sanchez Y (2004) Chk1 in the DNA damage response: conserved roles from yeasts to mammals. DNA Repair (Amst) 3(8-9):1025-32 SGD PMID 15279789
- ↑ Liu Y, et al. (2000) Characterization of a Saccharomyces cerevisiae homologue of Schizosaccharomyces pombe Chk1 involved in DNA-damage-induced M-phase arrest. Mol Gen Genet 262(6):1132-46 SGD PMID 10660074
- ↑ Rouse J and Jackson SP (2002) Interfaces between the detection, signaling, and repair of DNA damage. Science 297(5581):547-51 SGD PMID 12142523
- ↑ Wang H, et al. (2001) Pds1 phosphorylation in response to DNA damage is essential for its DNA damage checkpoint function. Genes Dev 15(11):1361-72 SGD PMID 11390356
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