YOR266W

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Systematic name YOR266W
Gene name PNT1
Aliases
Feature type ORF, Verified
Coordinates Chr XV:821022..822293
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Description of YOR266W: Mitochondrial inner membrane protein involved in export of proteins from the mitochondrial matrix; overexpression of PNT1 confers resistance to the anti-Pneumocystis carinii drug pentamidine, and deletion confers increased sensitivity[1][2]



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References

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  1. He S and Fox TD (1999) Mutations affecting a yeast mitochondrial inner membrane protein, pnt1p, block export of a mitochondrially synthesized fusion protein from the matrix. Mol Cell Biol 19(10):6598-607 SGD PMID 10490599
  2. Ludewig G and Staben C (1994) Characterization of the PNT1 pentamidine resistance gene of Saccharomyces cerevisiae. Antimicrob Agents Chemother 38(12):2850-6 SGD PMID 7695273

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