YDR440W
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Systematic name | YDR440W |
Gene name | DOT1 |
Aliases | PCH1 |
Feature type | ORF, Verified |
Coordinates | Chr IV:1342486..1344234 |
Primary SGDID | S000002848 |
Description of YDR440W: Nucleosomal histone H3-Lys79 methylase, associates with transcriptionally active genes, functions in gene silencing at telomeres, most likely by directly modulating chromatin structure and Sir protein localization[1][2][3]
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Contents
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References
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- ↑ Ng HH, et al. (2002) Lysine methylation within the globular domain of histone H3 by Dot1 is important for telomeric silencing and Sir protein association. Genes Dev 16(12):1518-27 SGD PMID 12080090
- ↑ Lacoste N, et al. (2002) Disruptor of telomeric silencing-1 is a chromatin-specific histone H3 methyltransferase. J Biol Chem 277(34):30421-4 SGD PMID 12097318
- ↑ Ng HH, et al. (2003) The Rtf1 component of the Paf1 transcriptional elongation complex is required for ubiquitination of histone H2B. J Biol Chem 278(36):33625-8 SGD PMID 12876293
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