Difference between revisions of "YLR008C"

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'''Description of {{PAGENAME}}:''' Constituent of the mitochondrial import motor associated with the presequence translocase, along with Ssc1p, Tim44p, Mge1p, and Pam16p; stimulates the ATPase activity of Ssc1p to drive mitochondrial import; contains a J domain<ref name='S000075099'>D'Silva PD, et al. (2003) J protein cochaperone of the mitochondrial inner membrane required for protein import into the mitochondrial matrix. Proc Natl Acad Sci U S A 100(24):13839-44 {{SGDpaper|S000075099}} PMID 14605210</ref><ref name='S000074354'>Truscott KN, et al. (2003) A J-protein is an essential subunit of the presequence translocase-associated protein import motor of mitochondria. J Cell Biol 163(4):707-13 {{SGDpaper|S000074354}} PMID 14638855</ref><ref name='S000074353'>Mokranjac D, et al. (2003) Tim14, a novel key component of the import motor of the TIM23 protein translocase of mitochondria. EMBO J 22(19):4945-56
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'''Description of {{PAGENAME}}:''' J-protein constituent of the mitochondrial import motor associated with the presequence translocase, with Ssc1p, Tim44p, Mge1p, and Pam16p; stimulates ATPase activity of Ssc1p to drive mitochondrial import; activity is inhibited by Pam16p<ref name='S000120441'>Mokranjac D, et al. (2006) Structure and function of Tim14 and Tim16, the J and J-like components of the mitochondrial protein import motor. EMBO J 25(19):4675-85 {{SGDpaper|S000120441}} PMID 16977310</ref><ref name='S000075099'>D'Silva PD, et al. (2003) J protein cochaperone of the mitochondrial inner membrane required for protein import into the mitochondrial matrix. Proc Natl Acad Sci U S A 100(24):13839-44 {{SGDpaper|S000075099}} PMID 14605210</ref><ref name='S000074354'>Truscott KN, et al. (2003) A J-protein is an essential subunit of the presequence translocase-associated protein import motor of mitochondria. J Cell Biol 163(4):707-13 {{SGDpaper|S000074354}} PMID 14638855</ref><ref name='S000074353'>Mokranjac D, et al. (2003) Tim14, a novel key component of the import motor of the TIM23 protein translocase of mitochondria. EMBO J 22(19):4945-56
 
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Specifically higher expression in carbon limited chemostat cultures versus carbon excess.
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Revision as of 13:02, 21 February 2007

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Systematic name YLR008C
Gene name PAM18
Aliases TIM14
Feature type ORF, Verified
Coordinates Chr XII:166082..165576


Description of YLR008C: J-protein constituent of the mitochondrial import motor associated with the presequence translocase, with Ssc1p, Tim44p, Mge1p, and Pam16p; stimulates ATPase activity of Ssc1p to drive mitochondrial import; activity is inhibited by Pam16p[1][2][3][4]




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References

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  1. Mokranjac D, et al. (2006) Structure and function of Tim14 and Tim16, the J and J-like components of the mitochondrial protein import motor. EMBO J 25(19):4675-85 SGD PMID 16977310
  2. D'Silva PD, et al. (2003) J protein cochaperone of the mitochondrial inner membrane required for protein import into the mitochondrial matrix. Proc Natl Acad Sci U S A 100(24):13839-44 SGD PMID 14605210
  3. Truscott KN, et al. (2003) A J-protein is an essential subunit of the presequence translocase-associated protein import motor of mitochondria. J Cell Biol 163(4):707-13 SGD PMID 14638855
  4. Mokranjac D, et al. (2003) Tim14, a novel key component of the import motor of the TIM23 protein translocase of mitochondria. EMBO J 22(19):4945-56 SGD PMID 14517234

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