YLR008C
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| Systematic name | YLR008C |
| Gene name | PAM18 |
| Aliases | TIM14 |
| Feature type | ORF, Verified |
| Coordinates | Chr XII:166083..165577 |
| Primary SGDID | S000003998 |
Description of YLR008C: Constituent of the import motor (PAM complex) component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); essential J-protein cochaperone that stimulates Ssc1p ATPase activity to drive import; inhibited by Pam16p[1][2][3][4]
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References
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- ↑ D'Silva PD, et al. (2003) J protein cochaperone of the mitochondrial inner membrane required for protein import into the mitochondrial matrix. Proc Natl Acad Sci U S A 100(24):13839-44 SGD PMID 14605210
- ↑ Mokranjac D, et al. (2003) Tim14, a novel key component of the import motor of the TIM23 protein translocase of mitochondria. EMBO J 22(19):4945-56 SGD PMID 14517234
- ↑ Mokranjac D, et al. (2006) Structure and function of Tim14 and Tim16, the J and J-like components of the mitochondrial protein import motor. EMBO J 25(19):4675-85 SGD PMID 16977310
- ↑ Truscott KN, et al. (2003) A J-protein is an essential subunit of the presequence translocase-associated protein import motor of mitochondria. J Cell Biol 163(4):707-13 SGD PMID 14638855
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