Difference between revisions of "YML069W"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000004534 YML069W] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''POB3 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''POB3 '' | ||
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|nowrap| Chr XIII:135500..137158 | |nowrap| Chr XIII:135500..137158 | ||
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| − | | | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000004534 |
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| − | '''Description of | + | '''Description of YML069W:''' Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), which associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases<ref name='S000082428'>Biswas D, et al. (2005) The yeast FACT complex has a role in transcriptional initiation. Mol Cell Biol 25(14):5812-22 {{SGDpaper|S000082428}} PMID 15987999</ref><ref name='S000048981'>Brewster NK, et al. (1998) Characterization of the CP complex, an abundant dimer of Cdc68 and Pob3 proteins that regulates yeast transcriptional activation and chromatin repression. J Biol Chem 273(34):21972-9 {{SGDpaper|S000048981}} PMID 9705338</ref><ref name='S000043153'>Evans DR, et al. (1998) The yeast protein complex containing cdc68 and pob3 mediates core-promoter repression through the cdc68 N-terminal domain. Genetics 150(4):1393-405 {{SGDpaper|S000043153}} PMID 9832518</ref><ref name='S000061420'>Formosa T, et al. (2001) Spt16-Pob3 and the HMG protein Nhp6 combine to form the nucleosome-binding factor SPN. EMBO J 20(13):3506-17 {{SGDpaper|S000061420}} PMID 11432837</ref><ref name='S000052704'>Wittmeyer J and Formosa T (1997) The Saccharomyces cerevisiae DNA polymerase alpha catalytic subunit interacts with Cdc68/Spt16 and with Pob3, a protein similar to an HMG1-like protein. Mol Cell Biol 17(7):4178-90 {{SGDpaper|S000052704}} PMID 9199353</ref><ref name='S000131309'>Xin H, et al. (2009) yFACT induces global accessibility of nucleosomal DNA without H2A-H2B displacement. Mol Cell 35(3):365-76 |
| − | {{SGDpaper| | + | {{SGDpaper|S000131309}} PMID 19683499</ref> |
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==Community Commentary== | ==Community Commentary== | ||
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| + | Specifically higher expression in carbon limited chemostat cultures versus carbon excess. | ||
| + | <ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. | ||
| + | J Biol Chem 278(5):3265-74</ref> | ||
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==References== | ==References== | ||
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Latest revision as of 07:45, 23 January 2012
Share your knowledge...Edit this entry! <protect>
| Systematic name | YML069W |
| Gene name | POB3 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XIII:135500..137158 |
| Primary SGDID | S000004534 |
Description of YML069W: Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), which associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases[1][2][3][4][5][6]
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Contents
Community Commentary
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References
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- ↑ Biswas D, et al. (2005) The yeast FACT complex has a role in transcriptional initiation. Mol Cell Biol 25(14):5812-22 SGD PMID 15987999
- ↑ Brewster NK, et al. (1998) Characterization of the CP complex, an abundant dimer of Cdc68 and Pob3 proteins that regulates yeast transcriptional activation and chromatin repression. J Biol Chem 273(34):21972-9 SGD PMID 9705338
- ↑ Evans DR, et al. (1998) The yeast protein complex containing cdc68 and pob3 mediates core-promoter repression through the cdc68 N-terminal domain. Genetics 150(4):1393-405 SGD PMID 9832518
- ↑ Formosa T, et al. (2001) Spt16-Pob3 and the HMG protein Nhp6 combine to form the nucleosome-binding factor SPN. EMBO J 20(13):3506-17 SGD PMID 11432837
- ↑ Wittmeyer J and Formosa T (1997) The Saccharomyces cerevisiae DNA polymerase alpha catalytic subunit interacts with Cdc68/Spt16 and with Pob3, a protein similar to an HMG1-like protein. Mol Cell Biol 17(7):4178-90 SGD PMID 9199353
- ↑ Xin H, et al. (2009) yFACT induces global accessibility of nucleosomal DNA without H2A-H2B displacement. Mol Cell 35(3):365-76 SGD PMID 19683499
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