YML069W
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| Systematic name | YML069W |
| Gene name | POB3 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XIII:135500..137158 |
| Primary SGDID | S000004534 |
Description of YML069W: Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), which associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases[1][2][3][4][5][6]
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References
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- ↑ Biswas D, et al. (2005) The yeast FACT complex has a role in transcriptional initiation. Mol Cell Biol 25(14):5812-22 SGD PMID 15987999
- ↑ Brewster NK, et al. (1998) Characterization of the CP complex, an abundant dimer of Cdc68 and Pob3 proteins that regulates yeast transcriptional activation and chromatin repression. J Biol Chem 273(34):21972-9 SGD PMID 9705338
- ↑ Evans DR, et al. (1998) The yeast protein complex containing cdc68 and pob3 mediates core-promoter repression through the cdc68 N-terminal domain. Genetics 150(4):1393-405 SGD PMID 9832518
- ↑ Formosa T, et al. (2001) Spt16-Pob3 and the HMG protein Nhp6 combine to form the nucleosome-binding factor SPN. EMBO J 20(13):3506-17 SGD PMID 11432837
- ↑ Wittmeyer J and Formosa T (1997) The Saccharomyces cerevisiae DNA polymerase alpha catalytic subunit interacts with Cdc68/Spt16 and with Pob3, a protein similar to an HMG1-like protein. Mol Cell Biol 17(7):4178-90 SGD PMID 9199353
- ↑ Xin H, et al. (2009) yFACT induces global accessibility of nucleosomal DNA without H2A-H2B displacement. Mol Cell 35(3):365-76 SGD PMID 19683499
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