Difference between revisions of "YLR008C"
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| − | '''Description of YLR008C:''' J-protein | + | '''Description of YLR008C:''' Conserved, essential J-protein cochaperone, constituent of the import motor component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); stimulates ATPase activity of Ssc1p to drive import; inhibited by Pam16p<ref name='S000074353'>Mokranjac D, et al. (2003) Tim14, a novel key component of the import motor of the TIM23 protein translocase of mitochondria. EMBO J 22(19):4945-56 {{SGDpaper|S000074353}} PMID 14517234</ref><ref name='S000074354'>Truscott KN, et al. (2003) A J-protein is an essential subunit of the presequence translocase-associated protein import motor of mitochondria. J Cell Biol 163(4):707-13 {{SGDpaper|S000074354}} PMID 14638855</ref><ref name='S000075099'>D'Silva PD, et al. (2003) J protein cochaperone of the mitochondrial inner membrane required for protein import into the mitochondrial matrix. Proc Natl Acad Sci U S A 100(24):13839-44 {{SGDpaper|S000075099}} PMID 14605210</ref><ref name='S000120441'>Mokranjac D, et al. (2006) Structure and function of Tim14 and Tim16, the J and J-like components of the mitochondrial protein import motor. EMBO J 25(19):4675-85 |
{{SGDpaper|S000120441}} PMID 16977310</ref> | {{SGDpaper|S000120441}} PMID 16977310</ref> | ||
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Revision as of 14:05, 4 August 2009
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| Systematic name | YLR008C |
| Gene name | PAM18 |
| Aliases | TIM14 |
| Feature type | ORF, Verified |
| Coordinates | Chr XII:166082..165576 |
| Primary SGDID | S000003998 |
Description of YLR008C: Conserved, essential J-protein cochaperone, constituent of the import motor component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); stimulates ATPase activity of Ssc1p to drive import; inhibited by Pam16p[1][2][3][4]
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References
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- ↑ Mokranjac D, et al. (2003) Tim14, a novel key component of the import motor of the TIM23 protein translocase of mitochondria. EMBO J 22(19):4945-56 SGD PMID 14517234
- ↑ Truscott KN, et al. (2003) A J-protein is an essential subunit of the presequence translocase-associated protein import motor of mitochondria. J Cell Biol 163(4):707-13 SGD PMID 14638855
- ↑ D'Silva PD, et al. (2003) J protein cochaperone of the mitochondrial inner membrane required for protein import into the mitochondrial matrix. Proc Natl Acad Sci U S A 100(24):13839-44 SGD PMID 14605210
- ↑ Mokranjac D, et al. (2006) Structure and function of Tim14 and Tim16, the J and J-like components of the mitochondrial protein import motor. EMBO J 25(19):4675-85 SGD PMID 16977310
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