Difference between revisions of "YPL123C"

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'''Description of YPL123C:''' RNAse; member of the T(2) family of endoribonucleases<ref name='S000059474'>MacIntosh GC, et al. (2001) Characterization of Rny1, the Saccharomyces cerevisiae member of the T2 RNase family of RNases: unexpected functions for ancient enzymes? Proc Natl Acad Sci U S A 98(3):1018-23
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'''Description of YPL123C:''' Vacuolar RNase of the T(2) family, relocalizes to the cytosol where it cleaves tRNAs upon oxidative or stationary phase stress; promotes apoptosis under stress conditions and this function is independent of its catalytic activity<ref name='S000059474'>MacIntosh GC, et al. (2001) Characterization of Rny1, the Saccharomyces cerevisiae member of the T2 RNase family of RNases: unexpected functions for ancient enzymes? Proc Natl Acad Sci U S A 98(3):1018-23 {{SGDpaper|S000059474}} PMID 11158587</ref><ref name='S000129797'>Thompson DM and Parker R (2009) The RNase Rny1p cleaves tRNAs and promotes cell death during oxidative stress in Saccharomyces cerevisiae. J Cell Biol
  {{SGDpaper|S000059474}} PMID 11158587</ref>
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  {{SGDpaper|S000129797}} PMID 19332891</ref>
 
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Revision as of 14:05, 8 April 2009

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Systematic name YPL123C
Gene name RNY1
Aliases
Feature type ORF, Verified
Coordinates Chr XVI:318944..317640
Primary SGDID S000006044


Description of YPL123C: Vacuolar RNase of the T(2) family, relocalizes to the cytosol where it cleaves tRNAs upon oxidative or stationary phase stress; promotes apoptosis under stress conditions and this function is independent of its catalytic activity[1][2]




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References

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  1. MacIntosh GC, et al. (2001) Characterization of Rny1, the Saccharomyces cerevisiae member of the T2 RNase family of RNases: unexpected functions for ancient enzymes? Proc Natl Acad Sci U S A 98(3):1018-23 SGD PMID 11158587
  2. Thompson DM and Parker R (2009) The RNase Rny1p cleaves tRNAs and promotes cell death during oxidative stress in Saccharomyces cerevisiae. J Cell Biol SGD PMID 19332891

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