Difference between revisions of "YLR181C"

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'''Description of YLR181C:''' Multivesicular body (MVB) protein involved in endosomal protein sorting; binds to Vps20p and Vps4p; may regulate Vps4p function; bindsVps60p and may act at a late step in MVB formation; mutants show class E vacuolar-protein sorting defects<ref name='S000075670'>Shiflett SL, et al. (2004) Characterization of Vta1p, a class E Vps protein in Saccharomyces cerevisiae. J Biol Chem 279(12):10982-90 {{SGDpaper|S000075670}} PMID 14701806</ref><ref name='S000074185'>Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91 {{SGDpaper|S000074185}} PMID 14562095</ref><ref name='S000073931'>Yeo SC, et al. (2003) Vps20p and Vta1p interact with Vps4p and function in multivesicular body sorting and endosomal transport in Saccharomyces cerevisiae. J Cell Sci 116(Pt 19):3957-70
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'''Description of YLR181C:''' Multivesicular body (MVB) protein involved in endosomal protein sorting; regulates Vps4p activity by promoting its oligomerization; has an N-terminal Vps60- and Did2- binding domain, a linker region, and a C-terminal Vps4p binding domain<ref name='S000125252'>Xiao J, et al. (2008) Structural basis of vta1 function in the multivesicular body sorting pathway. Dev Cell 14(1):37-49 {{SGDpaper|S000125252}} PMID 18194651</ref><ref name='S000120430'>Azmi I, et al. (2006) Recycling of ESCRTs by the AAA-ATPase Vps4 is regulated by a conserved VSL region in Vta1. J Cell Biol 172(5):705-17 {{SGDpaper|S000120430}} PMID 16505166</ref><ref name='S000075670'>Shiflett SL, et al. (2004) Characterization of Vta1p, a class E Vps protein in Saccharomyces cerevisiae. J Biol Chem 279(12):10982-90 {{SGDpaper|S000075670}} PMID 14701806</ref><ref name='S000074185'>Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91 {{SGDpaper|S000074185}} PMID 14562095</ref><ref name='S000073931'>Yeo SC, et al. (2003) Vps20p and Vta1p interact with Vps4p and function in multivesicular body sorting and endosomal transport in Saccharomyces cerevisiae. J Cell Sci 116(Pt 19):3957-70
 
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  {{SGDpaper|S000073931}} PMID 12953057</ref>
 
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Revision as of 07:21, 26 February 2009

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Systematic name YLR181C
Gene name VTA1
Aliases
Feature type ORF, Verified
Coordinates Chr XII:517672..516680
Primary SGDID S000004171


Description of YLR181C: Multivesicular body (MVB) protein involved in endosomal protein sorting; regulates Vps4p activity by promoting its oligomerization; has an N-terminal Vps60- and Did2- binding domain, a linker region, and a C-terminal Vps4p binding domain[1][2][3][4][5]




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References

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  1. Xiao J, et al. (2008) Structural basis of vta1 function in the multivesicular body sorting pathway. Dev Cell 14(1):37-49 SGD PMID 18194651
  2. Azmi I, et al. (2006) Recycling of ESCRTs by the AAA-ATPase Vps4 is regulated by a conserved VSL region in Vta1. J Cell Biol 172(5):705-17 SGD PMID 16505166
  3. Shiflett SL, et al. (2004) Characterization of Vta1p, a class E Vps protein in Saccharomyces cerevisiae. J Biol Chem 279(12):10982-90 SGD PMID 14701806
  4. Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91 SGD PMID 14562095
  5. Yeo SC, et al. (2003) Vps20p and Vta1p interact with Vps4p and function in multivesicular body sorting and endosomal transport in Saccharomyces cerevisiae. J Cell Sci 116(Pt 19):3957-70 SGD PMID 12953057

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