YPR175W

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Systematic name YPR175W
Gene name DPB2
Aliases
Feature type ORF, Verified
Coordinates Chr XVI:888974..891043
Primary SGDID S000006379


Description of YPR175W: Second largest subunit of DNA polymerase II (DNA polymerase epsilon), required for maintenance of fidelity of chromosomal replication; expression peaks at the G1/S phase boundary; Cdc28p substrate[1][2][3]




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Protein Details

Protein Modification

Modification(s): Phosphorylation

Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [4] [5]





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References

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  1. Araki H, et al. (1991) DPB2, the gene encoding DNA polymerase II subunit B, is required for chromosome replication in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 88(11):4601-5 SGD PMID 2052544
  2. Jaszczur M, et al. (2008) Dpb2p, a Noncatalytic Subunit of DNA Polymerase {varepsilon}, Contributes to the Fidelity of DNA Replication in Saccharomyces cerevisiae. Genetics 178(2):633-47 SGD PMID 18245343
  3. Jaszczur M, et al. (2009) Defective interaction between Pol2p and Dpb2p, subunits of DNA polymerase epsilon, contributes to a mutator phenotype in Saccharomyces cerevisiae. Mutat Res 669(1-2):27-35 SGD PMID 19463834
  4. Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
  5. submitted by Jeff Ubersax on 2004-01-29

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