YPR158W
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| Systematic name | YPR158W |
| Gene name | CUR1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XVI:843262..844020 |
| Primary SGDID | S000006362 |
Description of YPR158W: Sorting factor, central regulator of spatial protein quality control; physically and functionally interacts with chaperones to promote sorting and deposition of misfolded proteins into cytosolic compartments; involved in destabilization of [URE3] prions; CUR1 has a paralog, BTN2, that arose from the whole genome duplication[1][2][3]
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References
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- ↑ Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61 SGD PMID 16169922
- ↑ Kryndushkin DS, et al. (2008) Curing of the [URE3] prion by Btn2p, a Batten disease-related protein. EMBO J 27(20):2725-35 SGD PMID 18833194
- ↑ Malinovska L, et al. (2012) Molecular chaperones and stress-inducible protein sorting factors coordinate the spatio-temporal distribution of protein aggregates. Mol Biol Cell () SGD PMID 22718905
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