YPR033C

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Systematic name YPR033C
Gene name HTS1
Aliases TSM4572
Feature type ORF, Verified
Coordinates Chr XVI:639019..637379
Primary SGDID S000006237


Description of YPR033C: Cytoplasmic and mitochondrial histidine tRNA synthetase; efficient mitochondrial localization requires both a presequence and an amino-terminal sequence; mutations in human ortholog HARS2 are associated with Perrault syndrome[1][2][3]




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References

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  1. Jump up Chiu MI, et al. (1992) HTS1 encodes both the cytoplasmic and mitochondrial histidyl-tRNA synthetase of Saccharomyces cerevisiae: mutations alter the specificity of compartmentation. Genetics 132(4):987-1001 SGD PMID 1459448
  2. Jump up Natsoulis G, et al. (1986) The HTS1 gene encodes both the cytoplasmic and mitochondrial histidine tRNA synthetases of S. cerevisiae. Cell 46(2):235-43 SGD PMID 3521891
  3. Jump up Pierce SB, et al. (2011) Mutations in mitochondrial histidyl tRNA synthetase HARS2 cause ovarian dysgenesis and sensorineural hearing loss of Perrault syndrome. Proc Natl Acad Sci U S A 108(16):6543-8 SGD PMID 21464306

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