YPL212C

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Systematic name YPL212C
Gene name PUS1
Aliases
Feature type ORF, Verified
Coordinates Chr XVI:153149..151515
Primary SGDID S000006133


Description of YPL212C: tRNA:pseudouridine synthase, introduces pseudouridines at positions 26-28, 34-36, 65, and 67 of tRNA; nuclear protein that appears to be involved in tRNA export; also acts on U2 snRNA[1][2]




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References

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  1. Grosshans H, et al. (2001) Pus1p-dependent tRNA pseudouridinylation becomes essential when tRNA biogenesis is compromised in yeast. J Biol Chem 276(49):46333-9 SGD PMID 11571299
  2. Massenet S, et al. (1999) Pseudouridine mapping in the Saccharomyces cerevisiae spliceosomal U small nuclear RNAs (snRNAs) reveals that pseudouridine synthase pus1p exhibits a dual substrate specificity for U2 snRNA and tRNA. Mol Cell Biol 19(3):2142-54 SGD PMID 10022901

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