YPL207W
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| Systematic name | YPL207W |
| Gene name | TYW1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XVI:159909..162341 |
| Primary SGDID | S000006128 |
Description of YPL207W: Iron-sulfer protein required for synthesis of Wybutosine modified tRNA; Wybutosine is a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions; induction by Yap5p in response to iron provides protection from high iron toxicity; overexpression results in increased cellular iron[1][2]
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References
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- Jump up ↑ Li L, et al. (2011) Yap5-regulated transcription of TYW1 protects yeast from high iron toxicity. J Biol Chem () SGD PMID 21917924
- Jump up ↑ Noma A and Suzuki T (2006) Ribonucleome analysis identified enzyme genes responsible for wybutosine synthesis. Nucleic Acids Symp Ser (Oxf) (50):65-6 SGD PMID 17150819
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