YPL157W
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| Systematic name | YPL157W |
| Gene name | TGS1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XVI:254814..255761 |
| Primary SGDID | S000006078 |
Description of YPL157W: Trimethyl guanosine synthase, conserved nucleolar methyl transferase that converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for nucleolar assembly and splicing of meiotic pre-mRNAs[1][2][3][4]
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References
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- ↑ Colau G, et al. (2004) The small nucle(ol)ar RNA cap trimethyltransferase is required for ribosome synthesis and intact nucleolar morphology. Mol Cell Biol 24(18):7976-86 SGD PMID 15340060
- ↑ Franke J, et al. (2008) Hypermethylation of yeast telomerase RNA by the snRNA and snoRNA methyltransferase Tgs1. J Cell Sci 121(Pt 21):3553-60 SGD PMID 18840651
- ↑ Mouaikel J, et al. (2002) Hypermethylation of the cap structure of both yeast snRNAs and snoRNAs requires a conserved methyltransferase that is localized to the nucleolus. Mol Cell 9(4):891-901 SGD PMID 11983179
- ↑ Qiu ZR, et al. (2011) An essential role for trimethylguanosine RNA caps in Saccharomyces cerevisiae meiosis and their requirement for splicing of SAE3 and PCH2 meiotic pre-mRNAs. Nucleic Acids Res () SGD PMID 21398639
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