YPL082C
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| Systematic name | YPL082C |
| Gene name | MOT1 |
| Aliases | BTAF1, BUR3, LPF4 |
| Feature type | ORF, Verified |
| Coordinates | Chr XVI:404083..398480 |
| Primary SGDID | S000006003 |
Description of YPL082C: Essential abundant protein involved in regulation of transcription, removes Spt15p (TBP) from DNA via its C-terminal ATPase activity, forms a complex with TBP that binds TATA DNA with high affinity but with altered specificity[1][2][3][4][5]
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References
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- Jump up ↑ Auble DT, et al. (1997) Molecular analysis of the SNF2/SWI2 protein family member MOT1, an ATP-driven enzyme that dissociates TATA-binding protein from DNA. Mol Cell Biol 17(8):4842-51 SGD PMID 9234740
- Jump up ↑ Collart MA (1996) The NOT, SPT3, and MOT1 genes functionally interact to regulate transcription at core promoters. Mol Cell Biol 16(12):6668-76 SGD PMID 8943321
- Jump up ↑ Davis JL, et al. (1992) A presumptive helicase (MOT1 gene product) affects gene expression and is required for viability in the yeast Saccharomyces cerevisiae. Mol Cell Biol 12(4):1879-92 SGD PMID 1312673
- Jump up ↑ Gumbs OH, et al. (2003) High-affinity DNA binding by a Mot1p-TBP complex: implications for TAF-independent transcription. EMBO J 22(12):3131-41 SGD PMID 12805227
- Jump up ↑ Muldrow TA, et al. (1999) MOT1 can activate basal transcription in vitro by regulating the distribution of TATA binding protein between promoter and nonpromoter sites. Mol Cell Biol 19(4):2835-45 SGD PMID 10082549
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