YPL058C

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Systematic name YPL058C
Gene name PDR12
Aliases
Feature type ORF, Verified
Coordinates Chr XVI:450377..445842
Primary SGDID S000005979


Description of YPL058C: Plasma membrane ATP-binding cassette (ABC) transporter, weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity[1][2][3][4]




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DNA and RNA Details

Other DNA and RNA Details

Other Topic: expression

Specifically lower expression in sulfur limited chemostat cultures versus sulfur excess. [5] [6]





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References

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  1. Decottignies A and Goffeau A (1997) Complete inventory of the yeast ABC proteins. Nat Genet 15(2):137-45 SGD PMID 9020838
  2. Holyoak CD, et al. (1999) The Saccharomyces cerevisiae weak-acid-inducible ABC transporter Pdr12 transports fluorescein and preservative anions from the cytosol by an energy-dependent mechanism. J Bacteriol 181(15):4644-52 SGD PMID 10419965
  3. Holyoak CD, et al. (2000) Loss of Cmk1 Ca(2+)-calmodulin-dependent protein kinase in yeast results in constitutive weak organic acid resistance, associated with a post-transcriptional activation of the Pdr12 ATP-binding cassette transporter. Mol Microbiol 37(3):595-605 SGD PMID 10931353
  4. Schuller C, et al. (2004) Global phenotypic analysis and transcriptional profiling defines the weak acid stress response regulon in Saccharomyces cerevisiae. Mol Biol Cell 15(2):706-20 SGD PMID 14617816
  5. Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. J Biol Chem 278(5):3265-74 SGD PMID 12414795
  6. submitted by Viktor Boer on 2003-07-25

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