YOR291W

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Systematic name YOR291W
Gene name YPK9
Aliases
Feature type ORF, Verified
Coordinates Chr XV:861175..865593
Primary SGDID S000005817


Description of YOR291W: Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome[1][2][3][4]




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Community Commentary

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Alleles, Strains, and Phenotypes

Complete Deletion

Phenotype(s): No Phenotype, Viable

No obvious phenotypes were detected upon deletion of YOR291w with a KanMX deletion cassette. The deletion was confirmed by PCR. [5] [6]


Phenotype(s): No Phenotype, Viable

No obvious phenotypes were detected upon deletion of YOR291w with a KanMX deletion cassette. The deletion was confirmed by PCR. [5] [6]





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References

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  1. Catty P, et al. (1997) The complete inventory of the yeast Saccharomyces cerevisiae P-type transport ATPases. FEBS Lett 409(3):325-32 SGD PMID 9224683
  2. Cronin SR, et al. (2002) Cod1p/Spf1p is a P-type ATPase involved in ER function and Ca2+ homeostasis. J Cell Biol 157(6):1017-28 SGD PMID 12058017
  3. Gitler AD, et al. (2009) Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity. Nat Genet 41(3):308-15 SGD PMID 19182805
  4. Schmidt K, et al. (2009) Cd2+, Mn2+, Ni2+ and Se2+ toxicity to Saccharomyces cerevisiae lacking YPK9p the orthologue of human ATP13A2. Biochem Biophys Res Commun 383(2):198-202 SGD PMID 19345671
  5. 5.0 5.1 Cronin SR, et al. (2000) Regulation of HMG-CoA reductase degradation requires the P-type ATPase Cod1p/Spf1p. J Cell Biol 148(5):915-24 SGD PMID 10704442
  6. 6.0 6.1 submitted by Stephen R. Cronin on 2003-06-13

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