YOR274W
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| Systematic name | YOR274W |
| Gene name | MOD5 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XV:837674..838960 |
| Primary SGDID | S000005800 |
Description of YOR274W: Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase; required for biosynthesis of the modified base isopentenyladenosine in mitochondrial and cytoplasmic tRNAs; gene is nuclear and encodes two isozymic forms; converts to a prion form, and prion conversion contributes to azole antifungal resistance by upregulating ergosterol biosynthesis[1][2][3][4]
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References
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- ↑ Dihanich ME, et al. (1987) Isolation and characterization of MOD5, a gene required for isopentenylation of cytoplasmic and mitochondrial tRNAs of Saccharomyces cerevisiae. Mol Cell Biol 7(1):177-84 SGD PMID 3031456
- ↑ Najarian D, et al. (1987) DNA sequence and transcript mapping of MOD5: features of the 5' region which suggest two translational starts. Mol Cell Biol 7(1):185-91 SGD PMID 3031457
- ↑ Slusher LB, et al. (1991) mRNA leader length and initiation codon context determine alternative AUG selection for the yeast gene MOD5. Proc Natl Acad Sci U S A 88(21):9789-93 SGD PMID 1946403
- ↑ Suzuki G, et al. (2012) A yeast prion, Mod5, promotes acquired drug resistance and cell survival under environmental stress. Science 336(6079):355-9 SGD PMID 22517861
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