YOL072W
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| Systematic name | YOL072W |
| Gene name | THP1 |
| Aliases | BUD29 |
| Feature type | ORF, Verified |
| Coordinates | Chr XV:194970..196337 |
| Primary SGDID | S000005433 |
Description of YOL072W: Nuclear pore-associated protein; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; contains a PAM domain implicated in protein-protein binding[1][2][3][4][5]
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References
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- ↑ Chekanova JA, et al. (2008) Sus1, Sac3, and Thp1 mediate post-transcriptional tethering of active genes to the nuclear rim as well as to non-nascent mRNP. RNA 14(1):66-77 SGD PMID 18003937
- ↑ Ciccarelli FD, et al. (2003) The PAM domain, a multi-protein complex-associated module with an all-alpha-helix fold. BMC Bioinformatics 4():64 SGD PMID 14687415
- ↑ Fischer T, et al. (2002) The mRNA export machinery requires the novel Sac3p-Thp1p complex to dock at the nucleoplasmic entrance of the nuclear pores. EMBO J 21(21):5843-52 SGD PMID 12411502
- ↑ Gallardo M, et al. (2003) Nab2p and the Thp1p-Sac3p complex functionally interact at the interface between transcription and mRNA metabolism. J Biol Chem 278(26):24225-32 SGD PMID 12702719
- ↑ Tous C, et al. (2011) A novel assay identifies transcript elongation roles for the Nup84 complex and RNA processing factors. EMBO J 30(10):1953-64 SGD PMID 21478823
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