YOL071W

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Systematic name YOL071W
Gene name EMI5
Aliases SDH5
Feature type ORF, Verified
Coordinates Chr XV:196507..196995
Primary SGDID S000005432


Description of YOL071W: Subunit of succinate dehydrogenase, which couples succinate oxidation to ubiquinone reduction; required for FAD cofactor attachment to Sdh1p; mutations in human ortholog PGL2 are associated with neuroendocrine tumors (paraganglioma)[1][2][3][4]




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References

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  1. Deutschbauer AM, et al. (2002) Parallel phenotypic analysis of sporulation and postgermination growth in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 99(24):15530-5 SGD PMID 12432101
  2. Enyenihi AH and Saunders WS (2003) Large-scale functional genomic analysis of sporulation and meiosis in Saccharomyces cerevisiae. Genetics 163(1):47-54 SGD PMID 12586695
  3. Hao HX, et al. (2009) SDH5, a gene required for flavination of succinate dehydrogenase, is mutated in paraganglioma. Science 325(5944):1139-42 SGD PMID 19628817
  4. Romano JD and Kolter R (2005) Pseudomonas-Saccharomyces interactions: influence of fungal metabolism on bacterial physiology and survival. J Bacteriol 187(3):940-8 SGD PMID 15659672

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