YOL021C
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| Systematic name | YOL021C |
| Gene name | DIS3 |
| Aliases | MTR17, RRP44 |
| Feature type | ORF, Verified |
| Coordinates | Chr XV:285426..282421 |
| Primary SGDID | S000005381 |
Description of YOL021C: Exosome core complex catalytic subunit; possesses both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase R and to human DIS3[1][2][3][4][5][6][7]
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References
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- ↑ Dziembowski A, et al. (2007) A single subunit, Dis3, is essentially responsible for yeast exosome core activity. Nat Struct Mol Biol 14(1):15-22 SGD PMID 17173052
- ↑ Lebreton A, et al. (2008) Endonucleolytic RNA cleavage by a eukaryotic exosome. Nature 456(7224):993-6 SGD PMID 19060886
- ↑ Liu Q, et al. (2006) Reconstitution, activities, and structure of the eukaryotic RNA exosome. Cell 127(6):1223-37 SGD PMID 17174896
- ↑ Lorentzen E, et al. (2008) Structure of the active subunit of the yeast exosome core, Rrp44: diverse modes of substrate recruitment in the RNase II nuclease family. Mol Cell 29(6):717-28 SGD PMID 18374646
- ↑ Schaeffer D, et al. (2009) The exosome contains domains with specific endoribonuclease, exoribonuclease and cytoplasmic mRNA decay activities. Nat Struct Mol Biol 16(1):56-62 SGD PMID 19060898
- ↑ Schneider C, et al. (2009) The N-terminal PIN domain of the exosome subunit Rrp44 harbors endonuclease activity and tethers Rrp44 to the yeast core exosome. Nucleic Acids Res 37(4):1127-40 SGD PMID 19129231
- ↑ Shiomi T, et al. (1998) Human dis3p, which binds to either GTP- or GDP-Ran, complements Saccharomyces cerevisiae dis3. J Biochem 123(5):883-90 SGD PMID 9562621
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