YOL018C
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| Systematic name | YOL018C |
| Gene name | TLG2 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XV:292074..290881 |
| Primary SGDID | S000005378 |
Description of YOL018C: Syntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation; homologous to mammalian SNARE protein syntaxin 16 (Sx16)[1][2][3][4]
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References
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- ↑ Bryant NJ and James DE (2001) Vps45p stabilizes the syntaxin homologue Tlg2p and positively regulates SNARE complex formation. EMBO J 20(13):3380-8 SGD PMID 11432826
- ↑ Coe JG, et al. (1999) A role for Tlg1p in the transport of proteins within the Golgi apparatus of Saccharomyces cerevisiae. Mol Biol Cell 10(7):2407-23 SGD PMID 10397773
- ↑ Dulubova I, et al. (2002) How Tlg2p/syntaxin 16 'snares' Vps45. EMBO J 21(14):3620-31 SGD PMID 12110575
- ↑ Struthers MS, et al. (2009) Functional homology of mammalian syntaxin 16 and yeast Tlg2p reveals a conserved regulatory mechanism. J Cell Sci 122(Pt 13):2292-9 SGD PMID 19509055
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