YOL010W
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| Systematic name | YOL010W |
| Gene name | RCL1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XV:307938..309041 |
| Primary SGDID | S000005370 |
Description of YOL010W: Endonuclease that cleaves pre-rRNA at site A2 for 18S rRNA biogenesis; subunit of U3-containing 90S preribosome processome complex involved in small ribosomal subunit assembly; stimulates Bms1p GTPase and U3 binding activity; similar to RNA cyclase-like proteins but no cyclase activity detected[1][2][3][4]
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References
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- ↑ Billy E, et al. (2000) Rcl1p, the yeast protein similar to the RNA 3'-phosphate cyclase, associates with U3 snoRNP and is required for 18S rRNA biogenesis. EMBO J 19(9):2115-26 SGD PMID 10790377
- ↑ Grandi P, et al. (2002) 90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors. Mol Cell 10(1):105-15 SGD PMID 12150911
- ↑ Horn DM, et al. (2011) RCL1, a novel nuclease for 18S rRNA production. J Biol Chem () SGD PMID 21849504
- ↑ Karbstein K, et al. (2005) An essential GTPase promotes assembly of preribosomal RNA processing complexes. Mol Cell 20(4):633-43 SGD PMID 16307926
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